Fig. 1From: Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genesGene expression of whole blood leukocytes in patients with RR as compared to patients without leprosy reactions. A group of genes differentially expressed in RR samples was identified, consisting of 1 chemokine gene (CCL2 logFC = 4.04), 2 PARK genes (PARK logFC =3.27, LRRK2 logFC =3.09), 1 eicosanoid metabolism gene (ALOX5 logFC =2.99), 4 pattern recognition receptor genes (Toll-like receptors -TLRs: TLR7 logFC =2.98, TLR10 logFC =3.07, TLR3 logFC =2.74, and C-lectin receptors-CLRs: CLEC5A logFC =2.81), 2 cytokine genes (IL18 logFC =2.34, IL15 logFC = 2.42) and 2 type I IFN genes (IFNB logFC =2.36, OAS1 logFC = 2.51)Back to article page