Skip to main content

Table 1 Baseline characteristics stratified by the first endpoint (adverse outcome)

From: Association of the Tyrosine/Nitrotyrosine pathway with death or ICU admission within 30 days for patients with community acquired pneumonia

Factor Level Total Non-adverse outcome at 30d Adverse outcome at 30d p-value
N   278 249 (89.6%) 29 (10.4%)  
Demographics
 Age in years median (IQR) 71.5 (57, 82) 71 (57, 82) 76 (67, 83) 0.078
 Gender, n (%) Male 165 (59.4%) 147 (59.0%) 18 (62.1%) 0.75
Female 113 (40.6%) 102 (41.0%) 11 (37.9%)  
 BMI, median (IQR) 24.8 (22.0, 27.7) 24.6 (21.8, 27.5) 26.6 (24.4, 29.5) 0.053
Comorbidities
 Coronary Heart Disease, n (%) 52 (18.7%) 44 (17.7%) 8 (27.6%) 0.2
 Congestive Heart Failure, n (%) 35 (12.6%) 31 (12.4%) 4 (13.8%) 0.84
 Chronic Kidney Disease, n (%) 67 (24.1%) 51 (20.5%) 16 (55.2%) < 0.001
 Diabetes mellitus, n (%) 41 (14.7%) 36 (14.5%) 5 (17.2%) 0.69
 Tumor, n (%) 33 (11.9%) 27 (10.8%) 6 (20.7%) 0.12
 COPD, n (%) 73 (26.3%) 61 (24.5%) 12 (41.4%) 0.051
Vital signs
 Pulse rate, bpm, median (IQR) 94 (82, 107) 94 (82.5, 106) 97 (75, 114) 0.75
 Temperature, °C, median (IQR) 38 (37.2, 38.9) 38 (37.2, 39) 37.4 (36.7, 38.4) 0.014
 Systolic BP, mmHg, median (IQR) 130 (118, 146) 131 (120, 147) 124 (102, 139) 0.044
Clinical scores
 PSI-Score 1, 2 73 (26.3%) 70 (28.1%) 3 (10.3%) < 0.001
3 56 (20.1%) 55 (22.1%) 1 (3.4%)  
4, 5 149 (53.6%) 124 (49.8%) 25 (86.2%)  
 CURB-65-Score 0, 1 125 (45.0%) 120 (48.2%) 5 (17.2%) < 0.001
2, 3 139 (50.0%) 123 (49.4%) 16 (55.2%)  
4, 5 14 (5.0%) 6 (2.4%) 8 (27.6%)  
Markers of oxidative stress and inflammation
 Tyrosine, median (IQR)   81.7 (63.2, 118.0) 81.6 (61.8, 117.0) 84.0 (66.4, 122.0) 0.33
 Tyr-NO2, median (IQR)   1.5 (0.8, 11.7) 1.5 (0.9, 12.3) 1.4 (0.5, 4.0) 0.29
 Ratio Tyr-NO2/Tyrosine, median (IQR) 2.0 (1.0, 7.6) 2.1 (1.0, 8.3) 1.9 (0.9, 3.5) 0.19
 CRP, median (IQR)   136 (63, 252) 132 (61, 246) 176 (106, 336) 0.032
 PCT, median (IQR)   0.45 (0.16, 3.20) 0.40 (0.15, 2.96) 0.64 (0.21, 6.30) 0.13
  1. Bolded p-values are statistically significant at p < 0.05. BMI, Body Mass Index; COPD, chronic obstructive pulmonary disease; bpm, beats per minute; BP, blood pressure; PSI Pneumonia Severity Index; CURB-65, score of confusion, urea, respiratory rate, blood pressure, age; CRP, initial C-reactive Protein level; PCT, initial Procalcitonin level; WBC, initial leukocyte count