Infectiona | Cut-off (mg/L) | Sensitivity% (95% CI) | Specificity% (95% CI) | PPV% (95% CI) | NPV% (95% CI) | LR+ (95% CI) | LR- (95% CI) | Diagnostic odds ratio (95% CI) |
---|---|---|---|---|---|---|---|---|
TB vs. CAP | CRP ≥64 | 90.2 (83.9–94.7) | 11.5 (4.7–22.2) | 69.0 (61.5–75.7) | 35.0 (15.4–59.2) | 1.02 (0.92–1.13) | 0.85 (0.36–2.03) | 1.20 (0.45–3.17) |
CRP < 175 | 65.4 (56.7–73.4) | 57.4 (44.1–70.0) | 77.0 (68.1–84.4) | 43.2 (32.2–54.7) | 1.53 (1.12–2.11) | 0.60 (0.44–0.83) | 2.55 (1.37–4.72) | |
CAP vs. PJP | CRP ≥ 63 | 90.2 (79.8–96.3) | 18.8 (4.0–45.6) | 80.9 (69.5–89.4) | 33.3 (7.5–70.1) | 1.11 (0.86–1.42) | 0.52 (0.15–1.87) | 2.12 (0.51–8.94) |
CRP ≥ 147 | 63.9 (50.6–75.8) | 87.5 (61.7–98.4) | 95.1 (83.5–99.4) | 38.9 (23.1–56.5) | 5.11 (1.38–18.96) | 0.41 (0.28–0.60) | 12.41 (2.83–59.7) | |
PJP vs. TB | CRP ≥33 | 93.8 (69.8–99.8) | 2.3 (0.5–6.5) | 10.3 (5.9–16.5) | 75.0 (19.4–99.4) | 0.96 (0.84–1.09) | 2.77 (0.31–25.08) | 0.35 (0.03–3.54) |
CRP < 147 | 87.5 (61.7–98.4) | 48.9 (40.1–57.7) | 17.1 (9.7–27.0) | 97.0 (89.6–99.6) | 1.71 (1.33–2.19) | 0.26 (0.07–0.95) | 6.69 (1.46–30.60) | |
TB vs. CAP/PJP | CRP ≥64 | 90.2 (83.9–94.7) | 13.0 (6.4–22.6) | 64.2 (56.8–71.0) | 43.5 (23.2–65.5) | 1.04 (0.94–1.15) | 0.75 (0.35–1.63) | 1.38 (0.58–3.25) |
CRP ≥150 | 48.9 (40.1–57.7) | 49.4 (37.8–61.0) | 62.5 (52.5–71.8) | 35.8 (26.8–45.7) | 0.96 (0.73–1.28) | 1.04 (0.78–1.37) | 0.93 (0.53–1.63) | |
CAP vs. TB/PJP | CRP ≥63 | 90.2 (79.8–96.3) | 10.7 (6.3–16.9) | 29.3 (22.9–36.3) | 72.7 (49.8–89.3) | 1.01 (0.91–1.12) | 0.92 (0.38–2.23) | 1.10 (0.42–2.87) |
CRP ≥175 | 57.4 (44.1–70.0) | 67.8 (59.6–75.2) | 42.2 (31.4–53.5) | 79.5 (71.5–86.2) | 1.78 (1.30–2.45) | 0.63 (0.46–0.86) | 2.83 (1.54–5.21) | |
PJP vs. TB/CAP | CRP ≥33 | 93.8 (69.8–99.8) | 2.6 (0.8–5.9) | 7.4 (4.2–11.8) | 83.3 (35.9–99.6) | 0.96 (0.85–1.09) | 2.42 (0.30–19.52) | 0.40 (0.04–3.62) |
CRP < 147 | 87.5 (61.7–98.4) | 53.6 (46.3–60.8) | 13.5 (7.6–21.6) | 98.1 (93.4–99.8) | 1.89 (1.48–2.40) | 0.23 (0.06–0.86) | 8.09 (1.99–36.55) |