Observational multi-centre, prospective study to characterize novel pathogen-and host-related factors in hospitalized patients with lower respiratory tract infections and/or sepsis - the “TAILORED-Treatment” study

Table 1 Eligible criteria for Tailored Treatment study

Inclusion criteria	Exclusion criteria
Age ≥ 1 month	Proven or suspected HIV, HBV, or HCV infection
Symptoms ≤8 days	Post-transplant
LRTI; ≥ 2 signs	Congenital immune deficiency
Respiratory rate > 20/min^a	Obvious alternative causes of respiratory distress
Chest cough	Nosocomial LRTI (> 3 days after hospitalization)
Nasal flaring	Other febrile infection during the past 3 weeks
Retractions	Active (haematological) malignancy
Rales	Immune-suppressive or immune-modulating therapies
Expiratory wheeze	Moderate to severe psychomotor retardation
Decreased breath sounds	Moderate to severe congenital metabolic disorder
Sepsis ^b ; ≥ 2 signs ^c
Heartrate > 90/min
Respiratory rate > 20/min
Core body temperature > 38 °C or < 36 °C
White blood cell count > 12,000 cells/ μl or < 4000/ μl

^aWHO age-specific criteria for tachypnea will be used for children [41]
^bAge-specific criteria for sepsis criteria according to the guidelines of the International Paediatric Sepsis Consensus Conference 2005 will be used for children [42]
^cOne of which must be abnormal temperature or white blood cell count
HIV human immunodeficiency virus, HBV hepatitis B virus, HCV hepatitis C virus

ISSN: 1471-2334