A case of Naegleria fowleri related primary amoebic meningoencephalitis in China diagnosed by next-generation sequencing

Table 1 Primary amoebic meningoencephalitis cases reported in China and neighboring places

Age	Gender	Location	Year	First CSF after admission					Amoebicidal Treatment	Days from symptom onset to death	Diagnosis
Age	Gender	Location	Year	WBC (cells/μL)	N %	L %	Glucose (mmol/L)	Protein (g/L)	Amoebicidal Treatment	Days from symptom onset to death	Diagnosis
17	male	Henan^b	1978	50	5	95	2.95	1.52	NA	10 days	Amoebic trophozoites were observed in the brain tissue after death.
21	male	Beijing^b	1990	300	70	30	3.4	0. 5	NA	7 days	Amoebic trophozoites were found in the CSF after death.
23	male	Hainan^b	2001	22,000	85	NA	2.2	2	none	6 days	Amoebic trophozoites were detected in the CSF before death.
38	male	Hong Kong	1993	NA	NA	NA	NA	NA	AmB, rifampicin	survival	Amoeba were observed in an abscess biopsy.
75	male	Taiwan	2011	560	90.5	5	2.2	9.5	AmB	25 days^a	Amoebic trophozoites were detected in the CSF.
42	male	Shenzhen	2016	1170	83	12	1	3	AmB, fluconazole	15 days	Next-generation sequencing

CSF Cerebrospinal fluid, WBC White blood cells, N Neutrophils, L Lymphocytes, NA Not available
^aDays after the start of AmB treatment
^bSuspected cases documented in Chinese journals without an English citation version

ISSN: 1471-2334