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Table 4 Univariable and multivariable analyses of factors associated with mortality for patients who were not on ART at start of TB treatment

From: HIV and TB co-infection in the ART era: CD4 count distributions and TB case fatality in Cape Town

  PYRS Deaths Univariable Multivariable
Characteristic    HR (95% CI) P-value aHR (95% CI) P-value
Calendar year
 2009 5169 823 1 0.03 1 0.38
 2010 5163 733 0.89 (0.81–0.98) < 0.001 1.05 (0.94–1.18) 0.66
 2011 4769 616 0.81 (0.73–0.90) < 0.001 1.03 (0.91–1.16) 0.09
 2012 3943 512 0.82 (0.73–0.91) < 0.001 1.12 (0.98–1.27) 0.55
 2013 3361 401 0.73 (0.65–0.83)   1.04 (0.91–1.21)  
Age (per 10 years increase) 22,405 3085 1.34 (1.30–1.39) < 0.001 1.38 (1.32–1.44) < 0.001
Female gender 11,662 1528 1 0.004 1 0.004
Male gender 10,743 1557 1.11 (1.03–1.19)   0.89 (0.82–0.96)  
Re-treatment TB 7142 1122 1   1  
New TB 15,263 1963 0.76 (0.71–0.82) < 0.001 0.67 (0.62–0.73) < 0.001
PTB 18,083 2391 1   1  
EPTB 4321 694 1.20 (1.11–1.31) < 0.001 1.25 (1.14–1.38) < 0.001
CD4 (per increase of 50 cells/mm3) 21,574 2807 0.85 (0.84–0.86) < 0.001 0.82 (0.81–0.83) < 0.001
Did not start ART 7037 1254 1   1  
Started ART 13,145 1301 0.56 (0.52–0.61) < 0.001 0.39 (0.35–0.42) < 0.001
  1. PYRS person years, HR Hazard Ratio, aHR Adjusted Hazard Ratio, CI confidence interval, TB tuberculosis, PTB pulmonary tuberculosis, EPTB extra-pulmonary tuberculosis, ART antiretroviral therapy