30 years of dengue fatal cases in Brazil: a laboratorial-based investigation of 1047 cases

BMC Infectious Diseases

Table 4 Logistic models with logit links of association of dengue serotype and Age with immune response that lead to the evolution to a dengue fatal outcome

Variable Factor (vs.)	Factor	n (fatal/non-fatal)	OR (95% CI)	p value
Serotype	Immune Responses
‘n’ Primary Responses	Immune Responses
DENV-1	Secondary	67 (5/62)	0.38 (0.14–0.96)	0.095
n = 57 (10/47)	Secondary	67 (5/62)	0.38 (0.14–0.96)	0.095
DENV-2	Secondary	140 (46/94)	0.83 (0.49–1.41)	0.558
n = 62 (23/39)	Secondary	140 (46/94)	0.83 (0.49–1.41)	0.558
DENV-3	Secondary	82 (19/63)	1.04 (0.60–1.79)	0.904
n = 138 (31/107)	Secondary	82 (19/63)	1.04 (0.60–1.79)	0.904
DENV-4	Secondary	4 (04/00)	–	–
n = 8 (03/05)	Secondary	4 (04/00)	–	–
Age	Immune Responses
(years old) ‘n’ Primary Responses	Immune Responses
0–15	Secondary	46 (24/22)	3.93 (1.86–8.62)	0.003
n = 46 (10/36)	Secondary	46 (24/22)	3.93 (1.86–8.62)	0.003
16–30	Secondary	63 (10/53)	0.6 (0.28–1.26)	0.267
n = 63 (15/48)	Secondary	63 (10/53)	0.6 (0.28–1.26)	0.267
31–50	Secondary	100 (19/81)	0.95 (0.52–1.76)	0.89
n = 86 (17/69)	Secondary	100 (19/81)	0.95 (0.52–1.76)	0.89
51–96	Secondary	51 (18/33)	1.83 (0.89–3.83)	0.172
n = 37 (18/19)	Secondary	51 (18/33)	1.83 (0.89–3.83)	0.172

To calculate each logistic GLM, Death/Alive outcome was coded as binary variable. Odd ratios (COR), 95% confidence intervals (95%CI) and p-values were calculated using one GLM for each studied variable separately. Values highlighted in bold presented: OR > 1, values of OR contained into the 95%CI range and p-values < 0.05

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