Table 2 Logistic Regression output to test the association between baseline characteristics and the risk of experiencing one or more grade 3 or 4 Adverse Event (AE) on standard TB therapy
From: Toxicity associated with tuberculosis chemotherapy in the REMoxTB study
Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
Baseline characteristic | OR | 95% CI | P value | adjOR | 95% CI | P value |
Female sex | 1.60 | 1.06–2.39 | 0.02 | 1.36 | 0.87–2.13 | 0.18 |
(2.10) | (1.21–3.65) | (0.01) | (1.97) | (0.91–1.83) | (0.03) | |
Age | 1.13 | 0.90–1.43 | 0.30 | 1.15 | 0.90–1.47 | 0.25 |
(1.25) | (0.89–1.74) | (0.20) | (1.29) | (0.91–1.83) | (0.16) | |
Baseline weight | 0.79 | 0.65–0.97 | 0.02 | 0.80 | 0.63–1.03 | 0.08 |
(0.86) | (0.65–1.14) | (0.30) | (0.90) | (0.67–1.21) | (0.49) | |
Ethnicity | ||||||
Black | Reference | *** | *** | *** | *** | *** |
Asian | 1.31 | 0.84–2.02 | 0.23 | *** | *** | *** |
(1.19) | (0.64–2.20) | (0.58) | ||||
Mix race | 0.72 | 0.42–1.24 | 0.24 | *** | *** | *** |
(0.71) | (0.32–1.56) | (0.40) | ||||
Smoking Hist. | ||||||
Never | Reference | *** | *** | *** | *** | *** |
Ex-smoker | 0.86 | 0.53–1.40 | 0.54 | *** | *** | *** |
(1.16) | (0.60–2.22) | (0.66) | ||||
Current | 0.90 | 0.57–1.42 | 0.64 | *** | *** | *** |
(0.82) | (0.42–1.60) | (0.56) | ||||
HIV positive | 3.45 | 1.86–6.42 | < 0.001 | 3.43 | 1.82–6.49 | < 0.01 |
(3.74) | (1.78–7.84) | (< 0.001) | (3.33) | (1.55–7.14) | (< 0.01) | |
Cavities on CXR | 1.03 | 0.62–1.71 | 0.92 | *** | *** | *** |
(0.62) | (0.31–1.21) | (0.16) | ||||
Baseline TTP | 1.24 | 0.55–2.82 | 0.60 | *** | *** | *** |
(1.39) | (0.47–4.09) | (0.55) | ||||