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Table 2 Logistic Regression output to test the association between baseline characteristics and the risk of experiencing one or more grade 3 or 4 Adverse Event (AE) on standard TB therapy

From: Toxicity associated with tuberculosis chemotherapy in the REMoxTB study

  Univariable analysis Multivariable analysis
Baseline characteristic OR 95% CI P value adjOR 95% CI P value
Female sex 1.60 1.06–2.39 0.02 1.36 0.87–2.13 0.18
(2.10) (1.21–3.65) (0.01) (1.97) (0.91–1.83) (0.03)
Age 1.13 0.90–1.43 0.30 1.15 0.90–1.47 0.25
(1.25) (0.89–1.74) (0.20) (1.29) (0.91–1.83) (0.16)
Baseline weight 0.79 0.65–0.97 0.02 0.80 0.63–1.03 0.08
(0.86) (0.65–1.14) (0.30) (0.90) (0.67–1.21) (0.49)
Ethnicity
 Black Reference *** *** *** *** ***
 Asian 1.31 0.84–2.02 0.23 *** *** ***
(1.19) (0.64–2.20) (0.58)
 Mix race 0.72 0.42–1.24 0.24 *** *** ***
(0.71) (0.32–1.56) (0.40)
Smoking Hist.
 Never Reference *** *** *** *** ***
 Ex-smoker 0.86 0.53–1.40 0.54 *** *** ***
(1.16) (0.60–2.22) (0.66)
 Current 0.90 0.57–1.42 0.64 *** *** ***
(0.82) (0.42–1.60) (0.56)
HIV positive 3.45 1.86–6.42 < 0.001 3.43 1.82–6.49 < 0.01
(3.74) (1.78–7.84) (< 0.001) (3.33) (1.55–7.14) (< 0.01)
Cavities on CXR 1.03 0.62–1.71 0.92 *** *** ***
(0.62) (0.31–1.21) (0.16)
Baseline TTP 1.24 0.55–2.82 0.60 *** *** ***
(1.39) (0.47–4.09) (0.55)
  1. Univariable odds ratio (OR) shown and characteristics with p value < 0.10 were manually added to a multivariable model to test for association. A random-effects multivariable logistic regression model was used with trial centre as the panels. ORs for experiencing any grade 3 or 4 AE shown with ORs for experiencing one or more related grade 3 or 4 AE provided in brackets. Baseline variables indicated in the table where necessary. Age and weight were entered as categorical variables shown in Table 2, and baseline time to MGIT positive (TTP) was entered as binary variable of below or above/equal to the median. Age, gender and baseline weight were included in the multivariable model regardless of p value due to clinical significance
  2. ***No analysis performed