Table 1 Baseline characteristics of patients in the standard therapy arm
From: Toxicity associated with tuberculosis chemotherapy in the REMoxTB study
Total | ≥1 Grade 3/4 AEs | ≥1 Related Grade 3/4 AEs | |
|---|---|---|---|
No of subjects | 639 | 128 | 57 |
(% total) | (20.0%) | (8.9%) | |
Gender (%) | |||
Male | 447 | 79 (17.7%) | 31 (6.9%) |
Female | 192 | 49 (25.5%) | 26 (13.5%) |
Age | |||
<25yrs | 187 | 37 (19.8%) | 11 (5.9%) |
25–35yrs | 184 | 29 (15.8%) | 20 (10.9%) |
>35yrs | 268 | 62 (23.1%) | 26 (9.7%) |
Baseline Weight | |||
<40kg | 63 | 18 (28.6%) | 8 (12.7%) |
40–45kg | 103 | 29 (28.2%) | 14 (13.6%) |
>45–55kg | 254 | 40 (19.7%) | 13 (5.1%) |
>55–75kg | 203 | 40 (19.7%) | 22 (10.8%) |
>75kg | 16 | 1 (6.2%) | 0 (0.0%) |
Median | 51.0 | 48.3 | 49.0 |
(IQR) | (45.0–57.7) | (42.3–57.0) | (42.5–58.0) |
Ethnicity (%) | |||
Black | 295 | 58 (19.7%) | 26 (8.8%) |
Asian | 194 | 47 (24.2%) | 20 (10.3%) |
Mixed Race | 140 | 21 (15.0%) | 9 (6.4%) |
Other | 10 | 2 (20.0%) | 2 (20.0%) |
Smoking Hist (%) | |||
Never | 298 | 63 (21.1%) | 27 (9.1%) |
Ex-smoker | 155 | 29 (18.7%) | 16 (10.3%) |
Current | 186 | 36 (19.3%) | 57 (7.5%) |
HIV Status | |||
Positive | 46 | 20 (43.5%) | 11 (23.9%) |
Negative | 593 | 108 (18.2%) | 46 (7.8%) |
Median CD4+ (IQR) | 365.5 (307.0–456.0) | 317.5 (267.5–458.5) | 340.0 (267.0–488.0) |
Cavities on CXR (%) | 456 | 90 (19.7%) | 32 (7.0%) |
MGIT Median TTP (IQR) | 114 (88–156) | 111 (86–163) | 118 (95–173) |