From: Medical treatment of cystic echinococcosis: systematic review and meta-analysis
Author/s. Year (Ref.no.) | Location Country | Objectivea | Study design | Trial time period | Participants | Sample size (N)b | No. Cysts | Patients characteristicsc | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Bildik N, et al. 2007 [33] | Kartal-Istanbul, Turkey | To evaluate the efficacy of preoperative ABZ therapy | A randomized controlled trial | 1998–2003 | Patients with isolated hydatid cysts of the liver | 84 | 84 | Sex (M/F), 36/48 Range age (yr), (14–67) | ||||
Group I | Group II | Group III | Group IV-control group | |||||||||
n = 21 No.cyst = 21 | n = 21 No.cyst = 21 | n = 21 No.cyst = 21 | n = 21 No.cyst = 21 | |||||||||
Cobo F, et al. 1998 [9] | Pamplona-Navarra, Spain | To compare the effects of a combined medication of ABZ plus PZQ vs ABZ alone in the preoperative treatment | A randomized controlled trial | 1990–1997 | Patients with intra-abdominal hydatidosis | 62 → 47 | No data | Group I | Group II | Group III | ||
n Sex (M/F) Age (yr, mean ± SD[range]) Cyst/patient (mean[range]) | 19 → 12 6/6 47.9 (19–67) 1.17(1–3) | 17 → 14 11/3 51.1 (31–70) 1.57 (1–4) | 26 → 21 9/12 46.9 (18–75) 1.43 (1–5) | |||||||||
Davis A, et al. 1986 [34] | WHO, Geneva, Switzerland | First phase: Studies coordinated by the WHO were conducted in seven clinical centers on the chemotherapy of human echinococcosis with MBZ, ABZ and FBZ. | A multicenter randomized clinical trials (5 clinical centers, Beirut, Paris, Rome, Sofia and Zurich) | 1982–1984 | Adults patients, mainly, only 7% below 15 years | 121 | 121 | MBZ | FBZ | ABZ | ||
n = 121 Sex (M/F) = 63/58 No.cyst = 402 | 85 38/47 348 | 6 3/3 18 | 30 22/8 36 | |||||||||
Davis A, et al. 1989 [35] | WHO, Geneva, Switzerland | Second phase: To value the efficacy of ABZ and MBZ in human CE coordinated by WHO. | A multicenter randomized clinical trials (4 clinical centers, Beirut, Paris, Rome and Sofia) | 1985–1987 | Adults patients, mainly, only 4% below 15 years | 176 → 112 | 106 | ABZ | MBZ | |||
n = 112 Sex (M/F) = 47/65 Follow-up < 12 months = 44 Follow-up > 12 months = 68 No.cyst patients > 12 months = 106 | 67 27/40 21 46 76 | 45 20/25 23 22 30 | ||||||||||
Franchi C, et al. 1999 [36] | Rome, Italy | To evaluate the results obtained during long-term follow-up of a series of patients treated with benzimidazole carbamate | A randomized controlled trial | 1982–1997 | Patients with hydatidosis located in various body organs | 448 | 929 | Sex (M/F), 191/257 Age (yr, mean[range]), 52 (4–86) Follow-up (months, mean[range]), 22 (12–170) | ||||
MBZ | ABZ | |||||||||||
n No.cyst | 125 289 | 323 640 | ||||||||||
Gil-Grande LA, et al. 1993 [37] | Madrid, Spain | To assess the efficacy and safety of ABZ in a medical treatment | A randomized controlled trial | 1987–1991 | Patients with intra-abdominal hydatid disease | 66 → 55 | 55 | Group A | Group B | Control gr. | ||
n Sex (M/F) Age (yr, mean ± SD) No.cyst | 18 10/8 41.7 ± 14.2 18 | 19 12/7 47.3 ± 13.9 19 | 18 9/9 41.2 ± 17.3 18 | |||||||||
Keshmiri M, et al. 1999 [38] | Mashhad, Iran | To compare the effects of ABZ vs placebo in the treatment of hydatid cysts | A triple-blind parallel randomized clinical trial | 1994–1995 | Patients with hydatid cysts of the lung/pulmonary echinococcosis | 20All p. 15Treat. | 179All p. 150Treat. | Treatment group | Placebo group | |||
All p.d | Treat.d | All p.d | Treat.d | |||||||||
n Sex (M/F) Age (yr, mean ± SD) No.cyst Cyst/patient | 14 8/6 41 ± 15 137 12.2 ± 13.4 | 11 5/6 40 ± 17 124 16.3 ± 13.9 | 6 3/3 39 ± 17 42 10.8 ± 13.7 | 4 3/1 45 ± 17 26 8.8 ± 7.6 | ||||||||
Keshmiri M, et al. 2001 [39] | Mashhad, Iran | To evaluate the effect of ABZ on hydatid disease | A double-blind parallel-group randomized clinical trial | 1994–1995 | Patients with hydatid cysts of the lung and abdomen (including liver) | 29All p. 21Treat. | 240 All p. 203Treat. | Treatment group | Placebo group | |||
All p.d | Treat.d | All p.d | Treat.d | |||||||||
n Sex (M/F) Age (yr, mean ± SD) No.cyst Cyst/patient | 22 11/11 41.4 ± 15.9 191 8.6 ± 9.0 | 17 7/10 40.5 ± 17.3 172 9.8 ± 9.9 | 7 4/3 35.4 ± 18.3 49 7.1 ± 6.5 | 4 3/1 45.5 ± 17.4 31 7.8 ± 6.1 | ||||||||
Khuroo MS, et al. 1993 [40] | Srinagar, Kashmir, India | To compare the safety and efficacy of percutaneous drainage (PD) with ABZ therapy | A randomized controlled trial | 1989–1992 | Patients with hepatic hydatid cysts | 30 | 33 | PD | ABZ-PD | ABZ | ||
n Sex (M/F) Age (yr, mean ± SD) (Range age) No.cyst Size Ø (cm, mean ± SD) Volume (cm3, mean ± SD) | 10 4/6 36.7 ± 12.3 (12–55) 10 9.2 ± 4.4 686 ± 651 | 10 3/7 41.3 ± 14.9 (12–64) 12 10.8 ± 3.0 835 ± 528 | 10 4/6 39.5 ± 14.4 (18–60) 11 8.8 ± 4.5 642 ± 717 | |||||||||
Mohamed AE, et al. 1998 [8] | Riyadh, Saudi Arabia | To evaluate the effect of different regimens of medical treatment | Two prospective randomized intervention studies | 1st study, 1985–1990 2nd study, 1990–1998 | Adult Saudi patients with hydatid disease at the Armed Forces Hospital | 1st, 22 2nd, 19, Total,41 | No data | 1st, ALB | 2nd, ABZ+PZQ | |||
n = 22 | n = 19 | |||||||||||
Shams-UI-Bari, et al. 2011 [41] | Srinagar, Kashmir, India | To assess the effect of preoperative ABZ therapy on the viability of protoscoleces at the time of surgery | A randomized controlled trial | 2002–2003 + follow-up 5 years | Patients with diagnosis of hydatid liver disease | 72 | 72 | Sex (M/F), 39/33 Range age (yr), (17–66) | ||||
Group A-Surgery | Group B-ABZ+surg+ABZ | |||||||||||
n Sex (M/F) Age (yr, mean ± SD[range]) No.cyst | 36 19/17 36.75 ± 11.34(16–64) 36 | 36 20/16 36.78 ± 11.79(17–62) 36 |