Table 3 Parameters during the follow-up in the ABC-reducing therapy group (n = 65). Dual therapy (DT) Alanine transaminase (ALT) Aspartate transaminase (AST) High-density lipoprotein (HDL) Low-density lipoprotein (HDL) Creatinine clearance (CCr) platelet-to-lymphocyte ratio (PLR) neutrophil-to-lymphocyte ratio (NLR)
Parameters | 12Â months before Mean (SD) | 6Â months before Mean (SD) | Swicht to DT Mean (SD) | 6Â months after switch Mean (SD) | 12Â months after switch Mean (SD) | From 12Â months before to switcha Coef. (CI 95%) | p-value | From switch to 12Â months aftera Coef. (CI 95%) | p-value |
|---|---|---|---|---|---|---|---|---|---|
CD4 cell count, cell/mm3 | 629.9 (327.7) | 656.6 (328) | 678.1 (342.2) | 677.4 (309.6) | 658.9 (265.4) | 1.3 (−2.3,4.9) | 0.481 | 1.6 (−2.4,5.5) | 0.435 |
CD8 cell count, cell/mm3 | 1023.5 (473.3) | 1069.7 (664) | 982.6 (461) | 992.6 (526.1) | 970.7 (446.6) | −2.5 (− 10.5,5.5) | 0.541 | − 1.3 (− 7.3,4.6) | 0.658 |
ALT (U/l) | 40.1 (41.6) | 43.5 (64.2) | 44.5 (47.7) | 45.9 (55.9) | 36.7 (34.8) | 0.4 (−0.9,1.6) | 0.580 | −0.2 (− 1.0,0.5) | 0.536 |
AST (U/l) | 30.2 (28.8) | 31.2 (42) | 29.6 (30) | 32.7 (32.4) | 30.1 (21.4) | 0.1 (−0.8,0.9) | 0.860 | −0.1 (− 0.6,0.4) | 0.761 |
Total Cholesterol (mg/dl) | 218.5 (44.3) | 220.8 (51.1) | 227.2 (48.8) | 218.4 (54.6) | 215.5 (39.2) | 0.6 (−0.3,1.5) | 0.218 | −1.6 (−2.6–0.6) | 0.003 |
HDL Cholesterol (mg/dl) | 47.2 (17.4) | 53.5 (19.6) | 49.8 (14.1) | 53.9 (19.5) | 52.8 (19.7) | 0.1 (−0.2,0.4) | 0.604 | 0.2 (−0.1,0.4) | 0.168 |
LDL Cholesterol (mg/dl) | 141.1 (38.3) | 133.4 (35.5) | 145.6 (42.4) | 138.4 (30.9) | 139.1 (27) | 0.2 (−0.9,1.3) | 0.742 | −0.7 (1.7,0.2) | 0.132 |
Triglycerides (mg/dl) | 163.8 (92.2) | 180.8 (110.9) | 202.8 (115.5) | 194.2 (234.4) | 172.5 (161.1) | 2.4 (0.3,4.6) | 0.027 | −3.8 (−8.4,0.9) | 0.112 |
CCr (ml/min) | 94.5 (31.5) | 97 (35.8) | 92.2 (26.8) | 91.6 (28.5) | 92.3 (30.9) | 0.0 (−0.4,0.3) | 0.852 | −0.4 (− 0.8–0.1) | 0.041 |
Lymphocyte, 103 /μL | 2201 (662) | 2197 (838) | 2191 (663) | 2256 (686) | 2219 (655) | 0.2 (−13.7,14.2) | 0.972 | 6.5 (− 7.8,20.8) | 0.373 |
Neutrophils, 103 /μL | 3227 (1354) | 3462 (1643) | 3851 (3336) | 3528 (1497) | 6059 (10610) | 40.7 (−32.7114.0) | 0.277 | 153.3 (−82.1388.7) | 0.202 |
Platelets, 103 /μL | 216,173 (63378) | 213,125 (68580) | 211,927 (59231) | 198,250 (60544) | 217,611 (59716) | −665.6 (− 1486.0, 154.7) | 0.112 | 98.2 (− 781.3977.8) | 0.827 |
NLR | 1.5 (0.6) | 1.7 (0.9) | 1.8 (1.3) | 1.7 (0.6) | 1.7 (0.7) | 0.2 (−0.2,0.5) | 0.367 | 0.0 (−0.02,0.03) | 0.840 |
PLR | 106.9 (46.1) | 108.5 (47.7) | 104 (36.6) | 92.5 (31.2) | 107.5 (42.4) | −0.4 (−1.3,0.5) | 0.378 | −0.2 (− 1.1,0.7) | 0.645 |
CD4/CD8 | 0.73 (0.42) | 0.76 (0.43) | 0.82 (0.47) | 0.81 (0.42) | 0.79 (0.38) | 0.005 (0.002,0.008) | 0.003 | 0.002 (−0.001,0.006) | 0.155 |