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Table 5 Pros and cons of serum, BALF and sputum samples for IPA diagnosis in non-haematological patients

From: Sputum signatures for invasive pulmonary aspergillosis in patients with underlying respiratory diseases (SPARED): study protocol for a prospective diagnostic trial

Samples

Pros

Cons

Serum

â–¡Convenient, cheap and fast

â–¡High specificity

â–¡Low sensitivity

BALF

â–¡Local-infection related

â–¡High sensitivity and specificity

â–¡Invasive, having contraindications

â–¡Expensive

Sputum

â–¡Convenient, cheap and fast

â–¡Local-infection related

â–¡Non-invasive

â–¡Affected by colonization and contamination