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Table 5 Pros and cons of serum, BALF and sputum samples for IPA diagnosis in non-haematological patients

From: Sputum signatures for invasive pulmonary aspergillosis in patients with underlying respiratory diseases (SPARED): study protocol for a prospective diagnostic trial

Samples Pros Cons
Serum □Convenient, cheap and fast
□High specificity
□Low sensitivity
BALF □Local-infection related
□High sensitivity and specificity
□Invasive, having contraindications
□Expensive
Sputum □Convenient, cheap and fast
□Local-infection related
□Non-invasive
□Affected by colonization and contamination