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Table 1 Sequence type changes in individual serotypes during the study periods

From: Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013

Serotype CC/ST (relation to confounder) CC percentage (n) of the serotype during n
Pre-PCV7 (1995–2003) Post-PCV7 (2004–2010) Post-PCV13 (2011–2013)
1 ST615 0 100 (1) 0 1
ST306 0 100 (1) 0 1
3 ST10002 0 100 (2) 0 2
CC320 0 100 (1) 0 1
 ST320 0 100 (1) 0 1
4 ST899 0 100 (2) 0 2
5 CC439 100 (1) 0 0 1
 ST3394 (SLV) 100 (1) 0 0 1
6A CC81 25.0 (1) 87.5 (7) 100 (4) 12
 ST81 25.0 (1) 62.5 (5) 50.0 (2) 8
 ST282 (SLV) 0 0 25.0 (1) 1
 ST2842 (SLV) 0 25.0 (2) 25.0 (1) 3
ST855 25.0 (1) 12.5 (1) 0 2
ST3166 25.0 (1) 0 0 1
ST3168 25.0 (1) 0 0 1
6B CC90 55.6 (5) 61.5 (8) 100 (1) 14
 ST90 11.1 (1) 0 0 1
 ST95 (SLV) 22.2 (2) 0 0 2
 ST1624 (SLV) 22.2 (2) 15.4 (2) 100 (1) 5
 ST3175 (SLV) 0 7.7 (1) 0 1
 ST3387 (SLV) 0 38.5 (5) 0 5
CC3173 11.1 (1) 38.5 (5) 0 6
 ST3173 11.1 (1) 30.8 (4) 0 5
 ST10274 (SLV) 0 7.7 (1) 0 1
ST3169 11.1 (1) 0 0 1
ST3171 22.2 (2) 0 0 2
6C CC81 0 0 100 (1) 1
 ST282 (SLV) 0 0 100 (1) 1
ST5241 0 100 (1) 0 1
6D CC81 0 100 (1) 0 1
 ST11978 (DLV) 0 100 (1) 0 1
7F ST191 0 100 (1) 0 1
9 V CC166 100 (3) 100 (8) 100 (1) 12
 ST166 66.7 (2) 75.0 (6) 100 (1) 9
 ST3383 (SLV) 33.3 (1) 0 0 1
 ST10120 (SLV) 0 25.0 (2) 0 2
10A ST3385 0 100 (5) 83.3 (5) 10
ST11189 0 0 16.7 (1) 1
11A CC166 0 50.0 (2) 100 (4) 6
 ST166 0 50.0 (2) 75.0 (3) 5
 ST10120 (SLV) 0 0 25.0 (1) 1
ST99 0 25.0 (1) 0 1
ST11188 0 25.0 (1) 0 1
12F ST220 0 100 (1) 0 1
ST6945 0 0 100 (1) 1
13 CC81 100 (1) 0 100 (3) 4
 ST189 (SLV) 100 (1) 0 66.7 (2) 3
 ST8420 (DLV) 0 0 33.3 (1) 1
14 CC81 18.2 (2) 0 0 2
 ST81 9.1 (1) 0 0 1
 ST3178 (SLV) 9.1 (1) 0 0 1
CC320 18.2 (2) 0 0 2
 ST328 (DLV) 18.2 (2) 0 0 2
CC554 54.5 (6) 100 (11) 100 (1) 18
 ST343 (SLV) 9.1 (1) 0 0 1
 ST554 27.3 (3) 18.2 (2) 100 (1) 6
 ST3177 (SLV) 9.1 (1) 27.3 (3) 0 4
 ST3388 (DLV) 9.1 (1) 0 0 1
 ST3600 (SLV) 0 9.1 (1) 0 1
 ST3601 (SLV) 0 45.5 (5) 0 5
ST13 9.1 (1) 0 0 1
15A CC81 0 50 (1) 100 (4) 5
 ST83 (SLV) 0 0 50 (2) 2
 ST1591 (SLV) 0 50 (1) 50 (2) 3
ST3414 0 50 (1) 0 1
15B/C CC81 100 (3) 20.0 (1) 22.2 (2) 6
 ST83 (SLV) 100 (3) 20.0 (1) 22.2 (2) 6
CC166 0 0 11.1 (1) 1
 ST166 0 0 11.1 (1) 1
ST3280 0 80.0 (4) 66.7 (6) 10
16F ST8351 0 0 100 1
18C ST870 0 66.7 (2) 0 2
ST3180 100 (1) 0 0 1
ST3594 0 33.3 (1) 0 1
19A CC320 90.0 (9) 100 (31) 100 (23) 63
 ST271 (SLV) 0 0 4.3 (1) 1
 ST320 90.0 (9) 90.3 (28) 91.3 (21) 58
 ST3159 (SLV) 0 0 4.3 (1) 1
 ST4465 (SLV) 0 3.2 (1) 0 1
 ST6398 (SLV) 0 3.2 (1) 0 1
 ST6400 (SLV) 0 3.2 (1) 0 1
ST1374 10.0 (1) 0 0 1
19F CC320 85.7 (6) 100 (16) 100 (2) 24
 ST236 (DLV) 42.9 (3) 6.3 (1) 0 4
 ST271 (SLV) 42.9 (3) 0 0 3
 ST320 0 43.8 (7) 0 7
 ST1464 (SLV) 0 43.8 (7) 50.0 (1) 8
 ST2697 (SLV) 0 0 50.0 (1) 1
 ST3390 (SLV) 0 6.3 (1) 0 1
ST2399 14.3 (1) 0 0 1
23A ST338 0 100 (4) 50.0 (2) 6
ST10272 0 0 50.0 (2) 2
23B CC439 0 0 50.0 (1) 1
 ST439 0 0 50.0 (1) 1
ST2372 0 0 50.0 (1) 1
23F CC81 50.0 (8) 36.4 (4) 0 12
 ST81 37.5 (6) 27.3 (3) 0 9
 ST83 (SLV) 0 9.1 (1) 0 1
 ST3392 (SLV) 6.3 (1) 0 0 1
 ST3415 (SLV) 6.3 (1) 0 0 1
CC880 50.0 (8) 63.6 (7) 100 (2) 17
 ST880 50.0 (8) 54.5 (6) 50.0 (1) 15
 ST3176 (SLV) 0 9.1 (1) 50.0 (1) 2
24F CC90 50.0 (1) 0 0 1
 ST3387 (SLV) 50.0 (1) 0 0 1
ST3386 0 0 100 (1) 1
ST3393 50.0 (1) 0 0 1
33F ST11188 0 100 (1) 100 (1) 2
34 CC9395 0 100 (3) 0 3
 ST9395 0 66.7 (2) 0 2
 ST11187 (SLV) 0 33.3 (1) 0 1
ST3116 100 (1) 0 0 1
35B CC558 100 (1) 100 (1) 0 2
 ST558 100 (1) 100 (1) 0 2
37 ST447 0 0 100 (1) 1
NT CC90 0 20.0 (1) 0 1
 ST3387 (SLV) 0 20.0 (1) 0 1
CC558 0 20.0 (1) 0 1
 ST558 0 20.0 (1) 0 1
ST310 0 20.0 (1) 0 1
ST447 0 20.0 (1) 0 1
ST3386 0 20.0 (1) 0 1
  1. CC clonal complex, ST sequence type, S singleton, PCV pneumococcal conjugate vaccine, n number, SLV single-locus variant, DLV double-locus variant, NT non-typeable