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Table 1 Specificity and genetic characteristics of mAbs isolated from two ZIKV infected individuals

From: Delayed and highly specific antibody response to nonstructural protein 1 (NS1) revealed during natural human ZIKV infection by NS1-based capture ELISA

mAb ID Origin Day Binding to NS1 (EC50)(ng/mL) Heavy chain Light chain
ZIKV DENV1 DENV2 DENV3 DENV4 V family CDR3 sequence V gene identity (%) V family CDR3 sequence V gene identity (%)
ZKns3G2 Pt1 188 34.5 N/A N/A N/A N/A IGHV3–53 ARERGWLDY 93.68 IGKV1–39 QQTYTIPRT 92.83
ZKns4F10 Pt1 188 10.9 N/A 116.1 N/A 351.4 IGHV4–31 ARAIDNFYDNSI 96.56 IGKV1–39 QQSYSPPYT 94.98
ZKns2E11 Pt2 66 9.8 N/A N/A N/A N/A IGHV3–30-3 ARVFNGYEGDY 95.83 IGLV3–10 YSTDSSGNLYV 97.49
ZKns14G5 Pt2 66 277.4 N/A N/A N/A N/A IGHV5–51 ARSNVDGSTDY 98.61 IGLV3–25 QSADSSDTYVPYV 98.92
ZKns4B8 Pt2 66 39.2 N/A N/A N/A N/A IGHV3–53 ASLGSGSAFGY 96.84 IGKV1–12 QQANSFPFT 98.21