Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

Table 3 Impact of precise co-morbidities on 28-day mortality

Co-morbidity	Odds ratio	95% confidence intervals	p-value
Patients with acute pyelonephritis
Chronic heart failure	2.54	1.82–3.55	< 0.0001
Chronic renal disease	1.71	1.13–2.60	0.011
Non-metastatic solid tumor malignancy	2.13	1.44–3.17	< 0.0001
Corticosteroid intake	2.05	1.09–3.84	0.024
Stroke	2.97	2.12–4.17	< 0.0001
Dementia	2.18	1.51–3.15	< 0.0001
Patients with community-acquired pneumonia
Coronary heart disease	1.87	1.30–2.69	0.001
Dementia	2.20	1.53–3.17	< 0.0001
Patients with intraabdominal infections
Type 2 diabetes mellitus	1.84	1.16–2.93	0.010
Chronic renal disease	2.67	1.12–6.35	0.026
Non-metastatic solid tumor malignancy	3.03	1.79–5.13	< 0.0001
Atrial fibrillation	2.23	1.11–4.48	0.024
Dementia	3.69	1.87–7.25	< 0.0001
Liver cirrhosis	4.59	1.20–17.51	0.025
Patients with primary bacteremia
Dementia	3.87	1.65–9.12	0.002

Only variables remaining significant after the final step of logistic forward conditional regression analysis are included

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