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Table 1 Comparison of demographics of patients without sepsis and with sepsis in relation to the underlying infection

From: Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

  Acute pyelonephritis Community-acquired pneumonia Intra-abdominal infections Primary bacteremia
No sepsis Sepsis p No sepsis Sepsis p No sepsis Sepsis p No sepsis Sepsis p
Number of patients 542 901   146 853   399 334   81 253  
Male gender
(n, %)
145 (26.8) 361 (40.0) < 0.0001 78
(53.4)
473 (55.4) 0.897 180
(45.2)
148
(45.1)
1.000 40
(49.4)
123
(48.6)
1.000
Age
(mean ± SD, years)
61.1 ± 22.0 74.8 ± 15.3 < 0.0001 61.4 ± 20.2 75.3 ± 14.9 < 0.0001 55.4 ± 24.3 74.7 ± 14.8 < 0.0001 63.3 ± 19.7 72.9 ± 14.5 < 0.0001
APACHE II score (mean ± SD) 9.2 ± 6.0 16.5 ± 7.4 < 0.0001 8.4 ± 4.8 18.4 ± 7.6 < 0.0001 7.5 ± 4.9 17.5 ± 8.9 < 0.0001 9.2 ± 4.6 19.8 ± 7.5 < 0.0001
SOFA score
(mean ± SD)
0.4 ± 0.5 5.9 ± 3.0 < 0.0001 0.7 ± 0.5 5.8 ± 3.2 < 0.0001 0.2 ± 0.5 5.3 ± 3.0 < 0.0001 0.5 ± 0.5 5.9 ± 3.4 < 0.0001
CCI
(mean ± SD)
3.0 ± 2.5 5.0 ± 2.6 < 0.0001 2.7 ± 2.3 4.8 ± 2.4 < 0.0001 2.3 ± 2.3 4.6 ± 2.4 < 0.0001 3.0 ± 2.0 4.5 ± 2.4 < 0.0001
28-day mortality
(n, %)
21
(3.9)
208 (23.1) < 0.0001 7
(4.8)
323 (37.9)* < 0.0001 17
(4.3)
109
(32.6)*
< 0.0001 4
(4.9)
98
(38.6)*
< 0.0001
  1. Abbreviations: APACHE acute physiology and chronic health evaluation, CCI Charlson’s comorbidity index, SOFA sequential organ failure assessment
  2. *p < 0.0001 compared to the respective mortality of acute pyelonephritis