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Table 4 Common RORC SNP haplotypes (rs9826/rs1521177) and their association with spontaneous viral clearance in the primary cohort and IFNL3 favorable sub-cohort

From: Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women

  Chronic HCVa Resolved HCVa P-value OR (95% CI)
Primary cohort
 T/T 0.62 0.79 0.0027 0.445(0.26–0.76)
 C/G 0.27 0.16 0.0315 1.893(1.05–3.40)
IFNL3 favorable sub-cohort
 T/T 0.64 0.78 0.0117 0.485(0.28–0.86)
 C/G 0.26 0.17 0.1042 1.672(0.90–3.12)
  1. aHaplotype frequency. Chi-square (χ2) tests were used to evaluate differences in haplotype frequencies between, HCV carriers and spontaneous resolvers, using SHEsis software. Haplotypes with frequencies < 0.05 (C/T, C/G, C/T, T/G) are not shown. P-values, odds ratios, (ORs) and 95% confidence intervals (95% CIs) were determined for association analysis. P-values (two-tailed) < 0.05 were considered significant (bold)