Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women

Table 4 Common RORC SNP haplotypes (rs9826/rs1521177) and their association with spontaneous viral clearance in the primary cohort and IFNL3 favorable sub-cohort

	Chronic HCV^a	Resolved HCV^a	P-value	OR (95% CI)
Primary cohort
T/T	0.62	0.79	0.0027	0.445(0.26–0.76)
C/G	0.27	0.16	0.0315	1.893(1.05–3.40)
IFNL3 favorable sub-cohort
T/T	0.64	0.78	0.0117	0.485(0.28–0.86)
C/G	0.26	0.17	0.1042	1.672(0.90–3.12)

^aHaplotype frequency. Chi-square (χ²) tests were used to evaluate differences in haplotype frequencies between, HCV carriers and spontaneous resolvers, using SHEsis software. Haplotypes with frequencies < 0.05 (C/T, C/G, C/T, T/G) are not shown. P-values, odds ratios, (ORs) and 95% confidence intervals (95% CIs) were determined for association analysis. P-values (two-tailed) < 0.05 were considered significant (bold)

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