Clonal diversity and genetic profiling of antibiotic resistance among multidrug/carbapenem-resistant Klebsiella pneumoniae isolates from a tertiary care hospital in Saudi Arabia

Table 3 Nucleotide polymorphism and allelic diversity among the loci of MLST

Locus	Length (bp)	No. alleles present	No. Polymorphic sites (%)	No. Synonymous mutations	No. Non-synonymous mutations	# SNPs	Ts	Tv	Ks	Ka	Ka/Ks	Diversity Index (π)
gapA	450	4	4 (0.89)	4	0	32	26	6	0.0060	NAN^a	–	0.00161126
InfB	318	5	4 (1.25)	4	0	69	69	0	0.0160	NAN	–	0.00393538
mdh	477	5	7 (1.47)	6	1	35	33	2	0.0050	0.0000	0.0000	0.0014328
pgi	432	3	2 (0.46)	2	0	9	0	9	0.0020	NAN	–	0.00055167
phoE	420	8	8 (1.90)	8	0	77	73	4	0.0230	NAN	–	0.00533477
rpoB	501	2	1 (0.20)	0	1	22	22	0	NAN	0.0010	–	0.00083368
tonB	414	10	13 (3.14)	7	6	192	103	89	0.0160	0.0060	0.3750	0.0089006
Concatenated	3012	0	39 (1.29)	31	8	436	326	110	0.0090	0.0010	0.1100	0.00304244

^aNot a number; SNP single nucleotide polymorphism, Ts Transitions, Tv Transversions, Ks Average number of nucleotide substitution per aynonymous site, Ka Average number of nucleotide substitution per non-synonymous site

ISSN: 1471-2334