Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis

Ning, Nian-zhi; Li, Tao; Zhang, Ju-ling; Qu, Fen; Huang, Jie; Liu, Xiong; Li, Zhan; Geng, Wei; Fu, Jun-liang; Huan, Wang; Zhang, Shu-yong; Bao, Chun-mei; Wang, Hui

doi:10.1186/s12879-018-3101-1

BMC Infectious Diseases

Table 1 Clinical and laboratory data of cirrhotic patients with BA and SBP

From: Clinical and bacteriological features and prognosis of ascitic fluid infection in Chinese patients with cirrhosis

	Total (n = 600)	BA (n = 192)	SBP (n = 408)	p
Sex (male)	465 (77.5%)	144 (75%)	321 (78.7%)	0.314
Age (yr)	53.9 ± 11.9	55.7 ± 12.1	53.1 ± 11.6	0.011
Presentation of symptoms	458 (76.3%)	118 (61.5%)	340 (83.3%)	< 0.001
Nosocomial infection	287 (47.8%)	84 (43.8%)	203 (49.8%)	0.17
MELD score	19.7 ± 9.5	16.3 ± 7.9	21.4 ± 9.8	< 0.001
Days in hospital	13 (7–19)	13 (7–18)	13 (7–19)	0.732
Days between admission and onset of infection	2 (0–9)	2 (0–6)	2 (0–10)	0.03
Causes of cirrhosis
Hepatitis B	370 (61.7%)	105 (54.7%)	265 (65%)	0.016
Hepatitis C	59 (9.8%)	24 (12.5%)	35 (8.6%)	0.132
Biliary	22 (3.7%)	7 (3.6%)	15 (3.7%)	0.985
Alcoholic	90 (15%)	37 (19.3%)	53 (13%)	0.044
Others	59 (9.8%)	19 (9.9%)	40 (9.8%)	0.972
Serum features
ALT(U/L)	35.0 (21.0–64.0)	30.0 (20.0–48.0)	38.0 (21.0–71.8)	0.001
AST(U/L)	60.0 (37.0–105.8)	53.0 (33.0–86.0)	65.5 (39.0–111.8)	0.004
Prealbumin(mg/L)	47.2 ± 25.8	55.3 ± 23.9	43.4 ± 25.8	< 0.001
Prothrombin time(S)	18.1 (15.0–22.6)	54.5 (40.2–68.0)	41.8 (26.0–57.7)	< 0.001
BUN(mmol/L)	8.0 (5.1–13.2)	6.4 (4.8–9.9)	8.9 (5.4–14.4)	< 0.001
Serum PMN(cells/μL)	5.4 (3.0–8.6)	4.0 (2.4–6.4)	6.2 (3.6–9.8)	< 0.001
Serum WBC(cells/μL)	6.9 (4.3–10.5)	5.4 (3.4–8.3)	7.7 (5.1–11.6)	< 0.001
Creatinine (μmol/L)	97.5 (78.0–138.8)	90.0 (70.2–111.8)	105.0 (82.0–157.0)	< 0.001
Total protein(g/L)	55.0 (49.0–61.0)	56.0 (51.0–63.0)	54.0 (48.0–60.0)	0.001
Total bilirubin (μmol/L)	82.4 (35.9–233.4)	51.5 (30.0–144.3)	107.9 (42.7–260.0)	< 0.001
Ascitic features
Ascitic PMN(cells/μL)	799.5 (53.1–5405.8)	22.9 (5.6–71.3)	3099.9 (720.2–7873.0)	< 0.001
Ascitic WBC(cells/μL)	1241.0 (253.3–6565.0)	169.0 (90.3–310.8)	3850.5 (1119.3–9826.8)	< 0.001
Hepatocellular carcinoma	175 (29.2%)	49 (25.5%)	126 (30.9%)	0.178
Hepatic encephalopathy	203 (33.8%)	58 (30.2%)	145 (35.5%)	0.198
Septic shock	108 (18%)	19 (9.9%)	89 (21.8%)	< 0.001
Upper gastrointestinal bleeding	114 (19%)	34 (17.7%)	80 (19.6%)	0.580
Diabetes mellitus	101 (16.8%)	37 (19.3%)	64 (15.7%)	0.274
30-day mortality	131 (21.8%)	26 (13.5%)	105 (25.7%)	0.001

Abbreviation: SBP spontaneous bacterial peritonitis, BA bacterascites, MELD Model for End-Stage Liver Disease, WBC white blood cell, PMN polymorphonuclear leukocytes, ALT alanine transarninase, AST aspartate aminotransferase, Bun blood urea nitrogen
P:compared between BA and SBP. P-values < 0.05 are indicated in bold

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