Table 3 Stratified analyses on PCV13 effectiveness according to age subgroups and immunological situation

50-64 years

n= 1,017,176

≥65 years

n=1,008,554

Compromised

n=176,054

Competent

n=1,849,676

 Number of events

350

1,298

401

1,247

 Multivariable HR

0.58

1.32

0.86

1.47

 (95% CI)

(0.20-1.67)

(0.81-2.18)

(0.44-1.69)

(0.81-2.68)

 p value

0.314

0.268

0.664

0.204

 Number of events

2,115

10,584

3,222

9,477

 Multivariable HR

1.21

1.76

1.51

1.86

  (95% CI)

(0.85-1.72)

(1.52-2.04)

(1.24-1.83)

(1.55-2.25)

 p value

0.283

<0.001

<0.001

<0.001

 Number of events

4,984

42,281

14,615

32,650

 Multivariable HR

1.01

1.06

1.01

1.10

 (95% CI)

(0.77-1.32)

(0.95-1.17)

(0.88-1.14)

(0.95-1.27)

 p value

0.951

0.309

0.928

0.217