Table 3 Risk factors for death. Univariate and multivariate Cox models
Univariate model | Multivariate model | |||
|---|---|---|---|---|
Hazard Ratio (95% confidence interval) | p-value | Hazard Ratio (95% confidence interval) | p-value | |
Region | < 0.01 | < 0.01 | ||
Eastern Europe | 1 | 1 | ||
Western/Southern Europe | 0.16(0.08–0.31) | 0.19 (0.09–0.39) | ||
Latin America | 0.42(0.25–0.70) | 0.44 (0.25–0.77) | ||
Age, years | 0.69 | 0.87 | ||
30 vs 20 | 1.07(0.64–1.80) | 1.12 (0.64–1.97) | ||
40 vs 20 | 1.07(0.47–2.42) | 1.29 (0.53–3.13) | ||
50 vs 20 | 0.93(0.43–2.00) | 1.53 (0.66–3.55) | ||
Male | 1.26(0.81–1.95) | 0.30 | 1.00 (0.62–1.60) | 0.99 |
Disseminated TB | 1.57(1.06–2.33) | 0.03 | 1.38 (0.92–2.06) | 0.12 |
IDU | 1.89(1.31–2.74) | < 0.01 | 1.19 (0.78–1.83) | 0.42 |
TB susceptibility | < 0.01 | 0.52 | ||
No MDR vs MDR | 0.41(0.24–0.71) | 0.72 (0.41–1.27) | ||
No Resistance test vs MDR | 0.52(0.31–0.88) | 0.84(0.49–1.46) | ||
Efavirenz | 1.47(0.96–2.24) | 0.07 | 1.13(0.72–1.78) | 0.59 |
ART naïve | 1.06(0.73–1.54) | 0.74 | 0.64(0.43–0.96) | 0.03 |
CD4+ at TB diagnosis (cells/mm3) | < 0.01 | < 0.01 | ||
100 vs 50 | 0.63(0.53–0.76) | 0.61(0.50–0.73) | ||
200 vs 50 | 0.35(0.25–0.51) | 0.33(0.23–0.48) | ||
350 vs 50 | 0.27(0.17–0.42) | 0.27(0.17–0.42) |