Fig. 6

Plasma levels of Filariasis composite antigen specific IgG3 and IgG4 in Loa loa microfilaraemia positive and negative ARV naïve HIV-1 infected people compared to seronegative people. As shown in (a) Loa loa microfilaraemia results to significantly (P < 0.0001) elevated plasma levels of antigen specific IgG3 in HIV-1 negative people on the one hand and a significant reduction (P < 0.0001) of antigen specific IgG3 in HIV-1 positive individuals on the other hand. Similarly in (e) Loa loa microfilaraemia results to significantly (P < 0.0001) higher plasma levels of antigen specific IgG4 in HIV-1 negative individuals in contrast to a significant reduction (P < 0.001) in HIV-1 positive individuals (compare HIV-/MF- with HIV-/MF+). Here the effect of Loa loa microfilaraemic HIV-1 infection was a significant reduction in plasma levels of filariasis composite antigen specific IgG3 (P < 0.0001) and IgG4 (P < 0.001). Statistical analysis was done with prism graph path 6.0, unpaired t test, Mann-Whitney-U tests and Kruskal-Wallis test