Table 1 General characteristics patients included in the study and its association with 5 year mortality
From: Risk factors for long-term mortality in patients admitted with severe infection
Variable | Total | Dead at 5 years | Crude OR (95% CI) | p value |
|---|---|---|---|---|
Age, median ± SD, years | 65 ± 20 | 74 ± 14 | 1.05 (1.04–1.05), per year | < 0.001 |
Female, n (%) | 517 (51) | 190 (50) | 1.06 (0.82–1.37) | 0.656 |
Underlying conditions, n (%) | ||||
Diabetes mellitus | 198 (20) | 85 (22) | 1.33 (0.97–1.83) | 0.074 |
Atherosclerosis | 236 (23) | 127 (34) | 2.43 (1.80–3.27) | < 0.001 |
Immunosuppression | 219 (22) | 75 (20) | 0.84 (0.61–1.15) | 0.274 |
Chemotherapy | 35 (4) | 26 (7) | ||
Radiotherapy | 8 (1) | 6 (2) | ||
Long-term corticoid | 168 (17) | 46 (12) | ||
Short-term corticoid | 22 (2) | 11 (3) | ||
HIV positive (non-AIDS) | 6 (1) | 1 (0) | ||
AIDS | 3 (0) | 2 (1) | ||
Chronic liver disease | 22 (2) | 14 (4) | 3.00 (1.25–7.22) | 0.014 |
Chronic heart failure | 74 (7) | 44 (12) | 2.64 (1.63–4.29) | < 0.001 |
Chronic respiratory disease | 66 (7) | 43 (11) | 3.40 (2.01–5.74) | < 0.001 |
Chronic kidney disease | 148 (15) | 56 (15) | 1.02 (0.71–1.46) | 0.908 |
End Stage kidney disease | 69 (7) | 23 (6) | 0.83 (0.49–1.39) | 0.469 |
Cancer | 45 (4) | 36 (10) | 7.29 (3.47–15.41) | < 0.001 |
Haematologic cancer | 59 (6) | 35 (9) | 2.59 (1.51–4.42) | 0.001 |
No comorbidities | 352 (35) | 78 (21) | 0.34 (0.25–0.46) | < 0.001 |
Karnofsky Index < 70 | 311 (31) | 195 (52) | 4.73 (3.56–6.29) | < 0.001 |
Type of infection | < 0.001 | |||
Community | 483 (48) | 144 (38) | 1.0 | |
Healthcare associated | 219 (22) | 106 (28) | 2.21 (1.59–3.07) | |
Hospital-acquired | 311 (31) | 129 (34) | 1.67 (1.24–2.25) | |
Severity of infection | < 0.001 | |||
Infection | 275 (27) | 86 (23) | 1.0 | |
Sepsis | 355 (35) | 125 (33) | 1.19 (0.85–1.67) | |
Severe sepsis | 292 (29) | 116 (31) | 1.45 (1.02–2.05) | |
Septic shock | 91 (9) | 52 (14) | 2.93 (1.80–4.77) | |
SAPS II score, per point | 29 ± 13 | 35 ± 14 | 1.07 (1.06–1.09) | < 0.001 |
SOFA score, per point | 2 ± 3 | 3 ± 3 | 1.11 (1.06–1.16) | < 0.001 |
Focus of infection | 0.043 | |||
Respiratory | 407 (40) | 156 (41) | 1.0 | |
Urinary | 339 (34) | 134 (35) | 1.05 (0.78–1.41) | |
Abdominal | 209 (21) | 62 (16) | 0.68 (0.47–0.97) | |
Other | 19 (2) | 14 (4) | 1.40 (0.81–2.43) | |
Microbiologic documentation | 691 (68) | 276 (73) | 1.41 (1.07–1.87) | 0.015 |
Positive blood cultures | 151 (15) | 70 (19) | 1.55 (1.09–2.19) | 0.014 |
Infection by a MDR pathogen | 322 (51) | 146 (56) | 1.42 (1.03–1.95) | 0.031 |
Infection by an ESKAPE pathogen | 113 (18) | 61 (24) | 1.88 (1.25–2.83) | 0.003 |
Inappropriate antibiotherapy | 144 (21) | 73 (26) | 1.74 (1.20–2.52) | 0.003 |