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Table 1 General characteristics patients included in the study and its association with 5 year mortality

From: Risk factors for long-term mortality in patients admitted with severe infection

Variable Total Dead at 5 years Crude OR (95% CI) p value
Age, median ± SD, years 65 ± 20 74 ± 14 1.05 (1.04–1.05), per year < 0.001
Female, n (%) 517 (51) 190 (50) 1.06 (0.82–1.37) 0.656
Underlying conditions, n (%)
 Diabetes mellitus 198 (20) 85 (22) 1.33 (0.97–1.83) 0.074
 Atherosclerosis 236 (23) 127 (34) 2.43 (1.80–3.27) < 0.001
 Immunosuppression 219 (22) 75 (20) 0.84 (0.61–1.15) 0.274
  Chemotherapy 35 (4) 26 (7)   
  Radiotherapy 8 (1) 6 (2)   
  Long-term corticoid 168 (17) 46 (12)   
  Short-term corticoid 22 (2) 11 (3)   
  HIV positive (non-AIDS) 6 (1) 1 (0)   
  AIDS 3 (0) 2 (1)   
 Chronic liver disease 22 (2) 14 (4) 3.00 (1.25–7.22) 0.014
 Chronic heart failure 74 (7) 44 (12) 2.64 (1.63–4.29) < 0.001
 Chronic respiratory disease 66 (7) 43 (11) 3.40 (2.01–5.74) < 0.001
 Chronic kidney disease 148 (15) 56 (15) 1.02 (0.71–1.46) 0.908
  End Stage kidney disease 69 (7) 23 (6) 0.83 (0.49–1.39) 0.469
  Cancer 45 (4) 36 (10) 7.29 (3.47–15.41) < 0.001
  Haematologic cancer 59 (6) 35 (9) 2.59 (1.51–4.42) 0.001
No comorbidities 352 (35) 78 (21) 0.34 (0.25–0.46) < 0.001
Karnofsky Index < 70 311 (31) 195 (52) 4.73 (3.56–6.29) < 0.001
Type of infection     < 0.001
 Community 483 (48) 144 (38) 1.0  
 Healthcare associated 219 (22) 106 (28) 2.21 (1.59–3.07)  
 Hospital-acquired 311 (31) 129 (34) 1.67 (1.24–2.25)  
Severity of infection     < 0.001
 Infection 275 (27) 86 (23) 1.0  
 Sepsis 355 (35) 125 (33) 1.19 (0.85–1.67)  
 Severe sepsis 292 (29) 116 (31) 1.45 (1.02–2.05)  
 Septic shock 91 (9) 52 (14) 2.93 (1.80–4.77)  
SAPS II score, per point 29 ± 13 35 ± 14 1.07 (1.06–1.09) < 0.001
SOFA score, per point 2 ± 3 3 ± 3 1.11 (1.06–1.16) < 0.001
Focus of infection     0.043
 Respiratory 407 (40) 156 (41) 1.0  
 Urinary 339 (34) 134 (35) 1.05 (0.78–1.41)  
 Abdominal 209 (21) 62 (16) 0.68 (0.47–0.97)  
 Other 19 (2) 14 (4) 1.40 (0.81–2.43)  
Microbiologic documentation 691 (68) 276 (73) 1.41 (1.07–1.87) 0.015
Positive blood cultures 151 (15) 70 (19) 1.55 (1.09–2.19) 0.014
Infection by a MDR pathogen 322 (51) 146 (56) 1.42 (1.03–1.95) 0.031
Infection by an ESKAPE pathogen 113 (18) 61 (24) 1.88 (1.25–2.83) 0.003
Inappropriate antibiotherapy 144 (21) 73 (26) 1.74 (1.20–2.52) 0.003
  1. CI Confidence interval, SD Standard deviation, HIV Human immunodeficiency virus, AIDS Acquired immunodeficiency syndrome, OR Odds ratio