Spoligotyping based genetic diversity of Mycobacterium tuberculosis in Ethiopia: a systematic review

Tulu, Begna; Ameni, Gobena

doi:10.1186/s12879-018-3046-4

BMC Infectious Diseases

Table 1 Description of reports on the strains of M. tuberculosis isolated from Ethiopia included in this review

From: Spoligotyping based genetic diversity of Mycobacterium tuberculosis in Ethiopia: a systematic review

Author	Study Region^a	Type of Patients^b	No. isolates	Typing method^c	No. strains	Clustering rate (%)	Shared rate^d (%)	Predominant strains	Lineage/Clade
Agonafir et al., 2010 [28]	AA	MDR-TB	107	Spoligotyping	81	80.43	82.61	SIT149	T, CAS
Deribew et al., 2012 [29]	OR	PTB	17	Spoligotyping	17	64.71	64.71	SIT777	T, H, CAS
Mihret et al., 2012 [30]	AA	PTB	192	Spoligotyping	192	82.81	88.02	SIT149	T, CAS, H
Ameni et al., 2013 [31]	OR	PTB	139	Spoligotyping	130	71.54	84.62	SIT149, SIT53	EA, EAI
Diriba et al., 2013 [32]	AA	MDR-TB	184	Spoligotyping	184	85.87	77.72	SIT21, SIT149	EA and IO
Firdessa et al., 2013 [17]	AA, AM, OR, SNNPR	PTB, ETB	950	Spoligotyping, MIRU-VNTR, SNP	950	62.21	81.79	SIT149, SIT25	EA, EAI
Garedew et al., 2013a [33]	AM	PTB	71	Spoligotyping	96	85.42	94.79	SIT149, SIT53	EA
Garedew et al., 2013b [34]	AM	ETB	44	Spoligotyping	44	79.54	95.45	SIT54, SIT53	EA, IO
Workalemahu et al., 2013 [36]	OR	Child TB	15	Spoligotyping	24	54.17	54.17	SIT37	EA
Yimer et al., 2013 [37]	AM	PTB	237	Spoligotyping and MIRU-VNTR	237	83.54	82.70	SIT25, SIT910	CAS_DELHI
Belay et al., 2014 [38]	AM	PTB	105	Spoligotyping	103	77.67	93.20	SIT149, SIT37	T3-ETH, T3
Debebe et al., 2014 [39]	AM	PTB	118	Spoligotyping	118	83.89	89.83	SIT25 and SIT53	EA, CAS
Disassa et al., 2015 [42]	BG	PTB	33	Spoligotyping	33	45.45	75.76	SIT53	EA
Gebrezgabiher et al., 2015 [43]	SNNPR	PTB, ETB	31	Spoligotyping	31	38.71	61.29	SIT53	EA
Getahun et al., 2015 [44]	ETH	PTB	92	Spoligotyping	91	70.33	58.24	SIT53, SIT149	EA, EAI
Korma et al., 2015 [45]	AA	ETB	58	Spoligotyping	58	60.34	82.76	SIT53, SIT149	T
Maru et al., 2015 [46]	AM	PTB	118	Spoligotyping	118	73.73	90.68	SIT25, SIT53	H, T, CAS-DELHI
Nuru et al., 2015 [47]	AM	PTB, ETB	168	Spoligotyping	168	58.33	72.62	SIT289, SIT134	EA, EAI
Zewudie et al., 2016 [51]	AA	PTB, ETB	73	Spoligotyping	73	61.64	79.45	SIT149, SIT53	T, CASI-DELHI
Nuru et al., 2017 [52]	AM	PTB, ETB	38	Spoligotyping	38	36.84	68.42	SIT53, SIT289	EA, EAI
Bedawi et al., 2017 [54]	OR & SNNPR	PTB	281	Spoligotyping	281	79.36	79.72	SIT53, SIT149	EA

^aAA Addis Ababa, AM Amhara, AF Afar, BG BenishangulGumz, DD Dire Dawa, GM Gambella, HR Harari, OR Oromia, SNNPR South Nation and Nationalities Peoples Region, SM Ethiopian Somali, TG Tigray. ^bPTB Pulmonary Tuberculosis, ETB Extra-pulmonary TB. ^cRFLP Restriction fragment length polymorphism, MIRU-VNTRs Mycobacterial interspersed repetitive units-variable tandem repeats of DNA tandem repeats. ^d The spoligo international type (SIT) numbers designate spoligotypes shared by two or more patient isolates

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ISSN: 1471-2334

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