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Table 4 Analysis of bacterial risk factors associated with unfavourable outcome during 2-year follow-up in 239 INH-resistant TB cases

From: Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis

Risk factor Crude OR 95%CI P-value Adjusted ORa 95% CI P-value
Age < 35 years (n = 97) 0.77 0.43–1.38 0.383 0.71 0.39–1.30 0.267
Male sex (n = 177) 0.80 0.43–1.50 0.494 0.82 0.43–1.56 0.542
Ethambutol resistance (n = 7) 0.99 0.19–5.20 0.986 0.95 0.17–5.16 0.952
Streptomycin resistance (n = 185) 0.68 0.36–1.30 0.246 0.53 0.27–1.06 0.074
Treatment with streptomycin (n = 63) 1.21 0.65–2.25 0.558 1.28 0.67–2.45 0.449
INH MIC > 1 μg/ml (n = 107) 1.15 0.46–2.89 0.558 1.33 0.52–3.40 0.557
Resistance mutation
 KatG 315 (n = 173 0.90 0.47–1.71 0.738 0.91 0.46–1.79 0.775
 InhA −15 (n = 18) 0.48 0.13–1.72 0.262 0.41 0.11–1.50 0.178
 Wild-type (n = 49) 1.53 0.75–3.10 0.243 1.69 0.79–3.64 0.177
Lineageb
 Beijing (n = 163) 2.82 1.41–5.66 0.003 3.16 1.54–6.47 0.002
 Euro-American (n = 31) 0.55 0.21–1.40 0.210 0.50 0.49–1.31 0.159
 Indo-Oceanic (n = 30) 0.58 0.22–1.48 0.250 0.54 0.21–1.40 0.204
  1. aadjusted for resistance to streptomycin and ethambutol
  2. b6 isolates had an unclassified lineage