Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis

BMC Infectious Diseases

Table 4 Analysis of bacterial risk factors associated with unfavourable outcome during 2-year follow-up in 239 INH-resistant TB cases

Risk factor	Crude OR	95%CI	P-value	Adjusted OR^a	95% CI	P-value
Age < 35 years (n = 97)	0.77	0.43–1.38	0.383	0.71	0.39–1.30	0.267
Male sex (n = 177)	0.80	0.43–1.50	0.494	0.82	0.43–1.56	0.542
Ethambutol resistance (n = 7)	0.99	0.19–5.20	0.986	0.95	0.17–5.16	0.952
Streptomycin resistance (n = 185)	0.68	0.36–1.30	0.246	0.53	0.27–1.06	0.074
Treatment with streptomycin (n = 63)	1.21	0.65–2.25	0.558	1.28	0.67–2.45	0.449
INH MIC > 1 μg/ml (n = 107)	1.15	0.46–2.89	0.558	1.33	0.52–3.40	0.557
Resistance mutation
KatG 315 (n = 173	0.90	0.47–1.71	0.738	0.91	0.46–1.79	0.775
InhA −15 (n = 18)	0.48	0.13–1.72	0.262	0.41	0.11–1.50	0.178
Wild-type (n = 49)	1.53	0.75–3.10	0.243	1.69	0.79–3.64	0.177
Lineage^b
Beijing (n = 163)	2.82	1.41–5.66	0.003	3.16	1.54–6.47	0.002
Euro-American (n = 31)	0.55	0.21–1.40	0.210	0.50	0.49–1.31	0.159
Indo-Oceanic (n = 30)	0.58	0.22–1.48	0.250	0.54	0.21–1.40	0.204

ISSN: 1471-2334