Phylogenetic Analysis of HDV nucleotide sequences. Phylogenetic tree of 55 HDV nucleic acid (n.a) patient sequences, 1 HDV-RNA sequence derived from HK293 cells transfected with HDV plasmid (2000504), and 17 prototype sequences obtained from GeneBank (dots, HDV genotype 1; triangle, HDV genotype 2-8) was constructed by Clustal W pairwise alignment with the 375 n.a. from HDVAg. The prototype sequences are identified by the HDV genotype and subtype , GeneBank accession number and the name of the country of origin (if known). The Israeli-identified sequences are defined by their patient and sample numbers. Bootstrap values are indicated for the major nodes as data obtained from 1000 replicates.