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Table 4 Predictors of progression to LRTI and pneumonia among all immunocompromised patients and stratified by age-groups (adults vs children)

From: Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study

  Univariable analyses Multivariable analyses
OR (95%CI) OR (95% CI) P value
Outcome: LRTI N = 215 (152 adults, 63 children)a
Increasing age (by 10Y range) All 1.2 (1.0;1.3) 1.1 (1.0;1.3) 0.048
Adults 1.3 (1.1;1.7) 1.2 (1.0;1.5) 0.128
Children 0.9 (0.3;2.8)
Bacterial co-infection All 3.3 (1.5;7.5) 3.4 (1.5;8.2) 0.005
Adults 3.2 (1.3;8.6) 3.4 (1.3;9.8) 0.018
Children 3.4 (0.8;17.5) 4.1 (0.9;24.6) 0.084
ALC All 1.0 (1.0;1.2) 1.0 (1.0;1.2) 0.501
Adults 1.1 (1.0;1.3) 1.0 (1.0;1.3) 0.580
Children 1.0 (0.6;1.4) 0.9 (0.6;1.3) 0.457
Type immunosuppression (compared to HSCT)
SOT All 0.9 (0.4;1.9) 0.7 (0.3;1.4) 0.294
Adults 1.0 (0.4;2.1) 0.7 (0.3;1.5) 0.344
Children 0.7 (0.1;6.4)
Leukemia/lymphoma All 1.0 (0.5;2.0) 1.0 (0.5;2.3) 0.935
Adults 2.0 (0.7;6.0) 1.2 (0.4;3.9) 0.791
Children 0.5 (0.1;2.7)
Solid tumor All 1.0 (0.4;2.5) 1.0 (0.4;2.6) 0.985
Adults 1.2 (0.4;3.8) 0.8 (0.2;2.8) 0.718
Children 0.7 (0.1;4.4)
Chronic immunosuppressive medication All 3.4 (1.2;10.4) 2.6 (0.9;8.3) 0.077
Adults 4.0 (1.3;15.6) 2.4 (0.7;10.2) 0.204
Children 2.0 (0.2;21.4)
PID All 0.6 (0.1;3.1) 0.7 (0.1;4.3) 0.724
Children 0.7 (0.1;6.4)
Outcome: LRTI N = 215 (152 adults, 63 children)a
Increasing age (by 10Y range) All 1.2 (1.1;1.4) 1.2 (1.1;1.4) 0.003
Bacterial co-infection All 3.1 (1.5;6.6) 3.6 (1.6;8.4) 0.002
ALC All 1.0 (1.0;1.1) 1.0 (1.0;1.1) 0.439
Type immunosuppression (compared to HSCT)
SOT All 0.7 (0.3;1.7) 0.5 (0.2;1.1) 0.094
Leukemia/lymphoma All 0.9 (0.4;2.1) 1.0 (0.4;2.5) 0.956
Solid tumor All 1.2 (0.5;3.2) 1.3 (0.4;3.6) 0.639
Chronic immunosuppressive medication All 2.0 (0.8;5.4) 1.4 (0.5;3.8) 0.540
PID All 0.4 (0.0;2.8) 0.7 (0.0;5.0) 0.721
  1. Absolute lymphocyte counts (ALC); Hematopoietic stem cell recipients (HSCT), Primary immunodeficiency disease (PID); Solid organ transplant (SOT);
  2. aN refers to the total number of patients included in all multivariable analyses for whom information on all predictors and outcomes was available. 24 patients (23 adults – 1 child) were excluded from univariable and multivariable analyses because of missing values for ALC
  3. Limited sample size in the pediatric subset limited the number of predictors which could be included in multivariable analyses for the outcome LRTI (−)