Diagnostic performance measure | Tests performance with LJ and /or MGIT MTB culture as reference standard | ||
---|---|---|---|
TB-LAMP performance (95% CI) | FM/ZN performance (95% CI) | Xpert MTB/Rif test performance (95% CI) | |
Sensitivity | 46/83, 55.4 (44.1-66.3) | 38/83, 45.8 (34.8-57.1) | 54/83, 65.1 (53.8-75.2) |
Specificity | 147/150, 98.0 (94.3-99.6) | 145/150, 96.7 (92.4-98.9) | 138/150, 92.0 (86.4-95.8) |
PPV | 46/49, 93.9 (83.1-98.7) | 38/43, 88.4 (74.9-96.1) | 54/66, 81.8 (70.4-90.2) |
NPV | 147/184, 79.9 (73.4-85.4) | 145/190, 76.3 (69.6- 82.2) | 138/167, 82.6% (76.0-88.1) |
LR (positive) | 27.7 (8.9-86.4) | 13.7 (5.62-33.6) | 8.13 (4.62-14.31) |
LR (negative) | 0.45 (0.36-0.58) | 0.60 (0.46-0.77) | 0.38 (0.28-0.51) |