Skip to main content

Table 3 Crude and adjusted odds ratio by hierarchical polytomous regression analysis of the association of characteristics of TB patients according to their M. tuberculosis isolates’ IS6110 RFLP cluster patterns (unique patterns for reference)

From: Risk factors associated with cluster size of Mycobacterium tuberculosis (Mtb) of different RFLP lineages in Brazil

  Crude OR Adjustment OR
Cluster Size Cluster Size
2–5 6–9 ≥ 10 2–5 6–9 ≥ 10
OR (CI) OR (CI) OR (CI) OR (CI) OR (CI) OR (CI)
Level 1
 Spoligotyping
  Non LAM Ref Ref Ref Ref Ref Ref
  LAM 1.08 (1.01–1.15) 1.18 (1.09–1.27) 1.22 (1.14–1.31) 1.08 (1.01–1.15) 1.17 (1.08–1.26) 1.22 (1.14–1.31)
 RDRio Genotype
  Non-RDRio Ref Ref Ref Ref Ref Ref
  RDRio 0.91 (0.81–1.03) 1.26 (1.15–1.38) 1.06 (0.94–1.19) 0.91 (0.80–1.03) 1.25 (1.14–1.37) 1.05 (0.93–1.18)
Level 2
 Metropolitan Area
  Vitoria Ref Ref Ref Ref Ref Ref
  Vila Velha 0.92 (0.55–1.55) 0.66 (0.28–1.53) 0.73 (0.33–1.62) 1.00 (0.59–1.69) 0.74 (0.30–1.77) 1.04 (0.46–2.36)
  Cariacica 1.02 (0.64–1.62) 0.70 (0.32–1.47) 1.27 (0.69–2.33) 1.12 (0.70–1.80) 0.71 (0.32–1.58) 1.81 (0.96–3.40)
  Serra 0.93 (0.59–1.45) 0.26 (0.09–0.75) 0.83 (0.43–1.60) 0.99 (0.63–1.55) 0.29 (0.10–0.84) 1.08 (0.55–2.11)
  Outros 0.62 (0.28–1.36) 0.71 (0.24–2.12) 0.86 (0.32–2.34) 0.66 (0.30–1.45) 0.74 (0.24–2.28) 1.04 (0.37–2.89)
Level 3
 Gender
  Female Ref Ref Ref Ref Ref Ref
  Male 1.01 (0.73–1.40) 1.16 (0.70–1.93) 1.20 (0.75–1.92) 0.98 (0.70–1.39) 1.19 (0.69–2.05) 1.20 (0.72–2.00)
 Age (years old)
   < 20 years Ref Ref Ref Ref Ref Ref
  21–30 years 0.48 (0.28–0.83) 0.42 (0.21–0.86) 0.96 (0.42–2.19) 0.49 (0.28–0.85) 0.45 (0.21–0.97) 1.13 (0.47–2.69)
  31–40 years 0.44 (0.25–0.77) 0.43 (0.21–0.88) 0.95 (0.41–2.19) 0.43 (0.24–0.77) 0.41 (0.19–0.90) 1.01 (0.42–2.43)
  41–50 years 0.62 (0.36–1.09) 0.31 (0.14–0.69) 0.79 (0.33–1.90) 0.61 (0.34–1.08) 0.30 (0.12–0.70) 0.93 (0.37–2.34)
   > 50 years 0.51 (0.28–0.93) 0.19 (0.07–0.50) 0.72 (0.28–1.81) 0.49 (0.26–0.91) 0.18 (0.06–0.49) 0.89 (0.33–2.37)
 Race
  White Ref Ref Ref Ref Ref Ref
  Black 0.97 (0.56–1.69) 1.27 (0.59–2.71) 2.59 (1.21–5.54) 0.82 (0.46–1.46) 0.79 (0.351.81) 2.02 (0.90–4.51)
  Others 0.96 (0.63–1.46) 0.90 (0.49–1.68) 1.68 (0.87–3.26) 0.89 (0.58–1.38) 0.76 (0.39–1.49) 1.53 (0.77–3.05)
 School level, years
   ≤ 4 years Ref Ref Ref Ref Ref Ref
  4 to 8 years 0.97 (0.58–1.62) 1.09 (0.50–2.37) 1.54 (0.67–3.53) 0.89 (0.52–1.51) 1.01 (0.42–2.41) 1.49 (0.62–3.57)
   ≥ 8 years 0.82 (0.42–1.58) 1.02 (0.38–2.73) 1.28 (0.46–3.58) 0.63 (0.31–1.27) 0.70 (0.24–2.12) 1.23 (0.41–3.70)
Level 4
 X-ray
  Negative Ref Ref Ref Ref Ref Ref
  Suspicious of TB 0.60 (0.30–1.17) 1.24 (0.35–4.29) 0.71 (0.27–1.84) 0.34 (0.14–0.79) 0.35 (0.08–1.56) 0.27 (0.08–0.92)
 Sputum smear results
  Negative Ref Ref Ref Ref Ref Ref
  Positive 0.88 (0.60–1.31) 2.68 (1.13–6.34) 1.69 (0.87–3.30) 0.69 (0.41–1.17) 2.05 (0.68–6.16) 1.24 (0.53–2.90)
 TB presentation
  PTB Ref Ref Ref Ref Ref Ref
  EPTB 0.65 (0.40–1.05) 0.41 (0.17–0.99) 0.46 (0.21–1.00) 0.44 (0.23–0.83) 0.41 (0.13–1.21) 0.37 (0.13–1.03)
  PTB + EPTB 1.08 (0.63–1.86) 0.26 (0.06–1.09) 0.65 (0.27–1.60) 0.94 (0.49–1.78) 0.29 (0.06–1.34) 0.68 (0.23–1.98)
  1. OR odds ratio, CI confidence interval, SD standard deviation, TB tuberculosis, PTB pulmonary TB, EPTB extrapulmonary TB. *Hierarchical levels: Level 1 = Spoligotyping + RDRio genotype; Level 2 = Spoligotyping + RDRio genotype + Metropolitan Area; Level 3 = Spoligotyping + RDRio genotype + Metropolitan Area + Gender +Age + Race + Schooling; Level  4 = Spoligotyping + RDRio genotype + Metropolitan Area + Gender +Age + Race + Schooling + X-Ray + Sputum smear results + TB presentation