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Table 3 Crude and adjusted odds ratio by hierarchical polytomous regression analysis of the association of characteristics of TB patients according to their M. tuberculosis isolates’ IS6110 RFLP cluster patterns (unique patterns for reference)

From: Risk factors associated with cluster size of Mycobacterium tuberculosis (Mtb) of different RFLP lineages in Brazil

 

Crude OR

Adjustment OR

Cluster Size

Cluster Size

2–5

6–9

≥ 10

2–5

6–9

≥ 10

OR (CI)

OR (CI)

OR (CI)

OR (CI)

OR (CI)

OR (CI)

Level 1

 Spoligotyping

  Non LAM

Ref

Ref

Ref

Ref

Ref

Ref

  LAM

1.08 (1.01–1.15)

1.18 (1.09–1.27)

1.22 (1.14–1.31)

1.08 (1.01–1.15)

1.17 (1.08–1.26)

1.22 (1.14–1.31)

 RDRio Genotype

  Non-RDRio

Ref

Ref

Ref

Ref

Ref

Ref

  RDRio

0.91 (0.81–1.03)

1.26 (1.15–1.38)

1.06 (0.94–1.19)

0.91 (0.80–1.03)

1.25 (1.14–1.37)

1.05 (0.93–1.18)

Level 2

 Metropolitan Area

  Vitoria

Ref

Ref

Ref

Ref

Ref

Ref

  Vila Velha

0.92 (0.55–1.55)

0.66 (0.28–1.53)

0.73 (0.33–1.62)

1.00 (0.59–1.69)

0.74 (0.30–1.77)

1.04 (0.46–2.36)

  Cariacica

1.02 (0.64–1.62)

0.70 (0.32–1.47)

1.27 (0.69–2.33)

1.12 (0.70–1.80)

0.71 (0.32–1.58)

1.81 (0.96–3.40)

  Serra

0.93 (0.59–1.45)

0.26 (0.09–0.75)

0.83 (0.43–1.60)

0.99 (0.63–1.55)

0.29 (0.10–0.84)

1.08 (0.55–2.11)

  Outros

0.62 (0.28–1.36)

0.71 (0.24–2.12)

0.86 (0.32–2.34)

0.66 (0.30–1.45)

0.74 (0.24–2.28)

1.04 (0.37–2.89)

Level 3

 Gender

  Female

Ref

Ref

Ref

Ref

Ref

Ref

  Male

1.01 (0.73–1.40)

1.16 (0.70–1.93)

1.20 (0.75–1.92)

0.98 (0.70–1.39)

1.19 (0.69–2.05)

1.20 (0.72–2.00)

 Age (years old)

   < 20 years

Ref

Ref

Ref

Ref

Ref

Ref

  21–30 years

0.48 (0.28–0.83)

0.42 (0.21–0.86)

0.96 (0.42–2.19)

0.49 (0.28–0.85)

0.45 (0.21–0.97)

1.13 (0.47–2.69)

  31–40 years

0.44 (0.25–0.77)

0.43 (0.21–0.88)

0.95 (0.41–2.19)

0.43 (0.24–0.77)

0.41 (0.19–0.90)

1.01 (0.42–2.43)

  41–50 years

0.62 (0.36–1.09)

0.31 (0.14–0.69)

0.79 (0.33–1.90)

0.61 (0.34–1.08)

0.30 (0.12–0.70)

0.93 (0.37–2.34)

   > 50 years

0.51 (0.28–0.93)

0.19 (0.07–0.50)

0.72 (0.28–1.81)

0.49 (0.26–0.91)

0.18 (0.06–0.49)

0.89 (0.33–2.37)

 Race

  White

Ref

Ref

Ref

Ref

Ref

Ref

  Black

0.97 (0.56–1.69)

1.27 (0.59–2.71)

2.59 (1.21–5.54)

0.82 (0.46–1.46)

0.79 (0.351.81)

2.02 (0.90–4.51)

  Others

0.96 (0.63–1.46)

0.90 (0.49–1.68)

1.68 (0.87–3.26)

0.89 (0.58–1.38)

0.76 (0.39–1.49)

1.53 (0.77–3.05)

 School level, years

   ≤ 4 years

Ref

Ref

Ref

Ref

Ref

Ref

  4 to 8 years

0.97 (0.58–1.62)

1.09 (0.50–2.37)

1.54 (0.67–3.53)

0.89 (0.52–1.51)

1.01 (0.42–2.41)

1.49 (0.62–3.57)

   ≥ 8 years

0.82 (0.42–1.58)

1.02 (0.38–2.73)

1.28 (0.46–3.58)

0.63 (0.31–1.27)

0.70 (0.24–2.12)

1.23 (0.41–3.70)

Level 4

 X-ray

  Negative

Ref

Ref

Ref

Ref

Ref

Ref

  Suspicious of TB

0.60 (0.30–1.17)

1.24 (0.35–4.29)

0.71 (0.27–1.84)

0.34 (0.14–0.79)

0.35 (0.08–1.56)

0.27 (0.08–0.92)

 Sputum smear results

  Negative

Ref

Ref

Ref

Ref

Ref

Ref

  Positive

0.88 (0.60–1.31)

2.68 (1.13–6.34)

1.69 (0.87–3.30)

0.69 (0.41–1.17)

2.05 (0.68–6.16)

1.24 (0.53–2.90)

 TB presentation

  PTB

Ref

Ref

Ref

Ref

Ref

Ref

  EPTB

0.65 (0.40–1.05)

0.41 (0.17–0.99)

0.46 (0.21–1.00)

0.44 (0.23–0.83)

0.41 (0.13–1.21)

0.37 (0.13–1.03)

  PTB + EPTB

1.08 (0.63–1.86)

0.26 (0.06–1.09)

0.65 (0.27–1.60)

0.94 (0.49–1.78)

0.29 (0.06–1.34)

0.68 (0.23–1.98)

  1. OR odds ratio, CI confidence interval, SD standard deviation, TB tuberculosis, PTB pulmonary TB, EPTB extrapulmonary TB. *Hierarchical levels: Level 1 = Spoligotyping + RDRio genotype; Level 2 = Spoligotyping + RDRio genotype + Metropolitan Area; Level 3 = Spoligotyping + RDRio genotype + Metropolitan Area + Gender +Age + Race + Schooling; Level  4 = Spoligotyping + RDRio genotype + Metropolitan Area + Gender +Age + Race + Schooling + X-Ray + Sputum smear results + TB presentation
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BMC Infectious Diseases

ISSN: 1471-2334

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