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Table 2 Characteristics and clinical course of the cases of acute biliary events

From: Acute biliary events during anti-tuberculosis treatment: hospital case series and a nationwide cohort study

  Case 1 Case 2 Case 3 Case 4
Age (decade of life) 9th 6th 6th 3rd
Sex male male male male
Co-morbidity DM DM, COPD HTN, COPD Nil
Anti-TB regimen before ABE HREZ HREZ HREZ HRE
Presenting symptoms Fever/Chills Nausea/Vomiting Fever Abdominal pain
Peak ALT level (U/L)a 375 303 16 499
Peak AST level (U/L)b 212 223 98 303
Peak total bilirubin level (mg/dL)c 2.81 1.53 1.69 0.57
Diagnosis of ABE Cholecystitis Cholecystitis Cholelithiasis with biliary obstruction Cholelithiasis with biliary obstruction
Onset of ABE 1 week later 4 weeks later 2 weeks later 18 weeks later
Treatment of ABE LC Antibiotics Antibiotics Antibiotics
  1. ABE Acute biliary event, ALT Alanine aminotransferase, AST Aspartate aminotransferase, COPD Chronic obstructive pulmonary disease, DM Diabetes mellitus, E Ethambutol, H Isoniazid, HTN Hypertension, LC laparoscopic cholecystectomy, R Rifampin, TB Tuberculosis, Z Pyrazinamide
  2. anormal range of ALT: 2–32 U/L
  3. bnormal range of AST: 10–30 U/L
  4. cnormal range of total bilirubin: 0.2–1.2 mg/dL