Acute biliary events during anti-tuberculosis treatment: hospital case series and a nationwide cohort study

BMC Infectious Diseases

Table 2 Characteristics and clinical course of the cases of acute biliary events

	Case 1	Case 2	Case 3	Case 4
Age (decade of life)	9th	6th	6th	3rd
Sex	male	male	male	male
Co-morbidity	DM	DM, COPD	HTN, COPD	Nil
Anti-TB regimen before ABE	HREZ	HREZ	HREZ	HRE
Presenting symptoms	Fever/Chills	Nausea/Vomiting	Fever	Abdominal pain
Peak ALT level (U/L)^a	375	303	16	499
Peak AST level (U/L)^b	212	223	98	303
Peak total bilirubin level (mg/dL)^c	2.81	1.53	1.69	0.57
Diagnosis of ABE	Cholecystitis	Cholecystitis	Cholelithiasis with biliary obstruction	Cholelithiasis with biliary obstruction
Onset of ABE	1 week later	4 weeks later	2 weeks later	18 weeks later
Treatment of ABE	LC	Antibiotics	Antibiotics	Antibiotics

ABE Acute biliary event, ALT Alanine aminotransferase, AST Aspartate aminotransferase, COPD Chronic obstructive pulmonary disease, DM Diabetes mellitus, E Ethambutol, H Isoniazid, HTN Hypertension, LC laparoscopic cholecystectomy, R Rifampin, TB Tuberculosis, Z Pyrazinamide
^anormal range of ALT: 2–32 U/L
^bnormal range of AST: 10–30 U/L
^cnormal range of total bilirubin: 0.2–1.2 mg/dL

ISSN: 1471-2334