Monitoring vaccine and non-vaccine HPV type prevalence in the post-vaccination era in women living in the Basilicata region, Italy

Table 5 HPV standardized prevalence (%) stratified by vaccination status and adjusted odds ratio evaluating association between HPV prevalence and vaccination status (women 18-24 years)

	HPV Prevalence % (N°)				Adjusted^a OR Vaccinated Before Sexual Debut vs Unvaccinated
HPV types	Unvaccinated (n = 295)	Vaccinated before sexual debut (n 295)	Vaccinated after sexual debut (n 294)	P-value^b	aOR (95% CI)	P-value
All types	20.0 (n 59)	14.6 (n 43)	18.4 (n 54)	0.08	0.89 (0.55-1.43)	0.630
HR types	16.6 (n 49)	9.5 (n 28)	15.3 (n 45)	0.01	0.62 (0.36-1.07)	0.088
LR types	7.5 (n 22)	6.8 (n 20)	7.5 (n 22)	0.74	1.19 (0.60-2.36)	0.613
Vaccine types	6.1 (n 18)	0.0 (n 0)	1.4 (n 4)	<0.001	0.00 (NE)	-
HR vaccine types (16,18)	5.8 (n 17)	0.0 (n 0)	1.4 (n 4)	<0.001	0.00 (NE)	-
LR vaccine types (6,11)	1.0 (n 3)	0.0 (n 0)	0.0 (n 0)	0.08	0.00 (NE)	-
Non-vaccine types^c	16.9 (n 50)	13.9 (n 41)	18.0 (n 53)	0.31	1.04 (0.63-1.70)	0.888
HPV 31	1.0 (n 3)	0.7 (n 2)	2.4 (n 7)	0.69	0.73 (0.12-4.57)	0.740
HPV 39	1.7 (n 5)	1.7 (n 5)	3.4 (n 10)	1.00	1.37 (0.36-5.26)	0.643
HPV 51	1.4 (n 4)	1.0 (n 3)	4.1 (n 12)	0.66	1.02 (0.20-5.05)	0.984
HPV 52	3.1 (n 9)	1.7 (n 5)	2.0 (n 6)	0.27	0.77 (0.24-2.50)	0.663
HPV 56	1.4 (n 4)	0.7 (n 2)	2.0 (n 6)	0.40	0.63 (0.11-3.78)	0.615
HPV 58	1.4 (n 4)	2.0 (n 6)	1.0 (n 3)	0.57	1.83 (0.47-7.12)	0.385
HPV 59	1.0 (n 3)	0.7 (n 2)	1.4 (n 4)	0.69	0.78 (0.13-4.82)	0.790
HPV 31, 33, 45	2.0 (n 6)	0.7 (n 2)	3.1 (n 9)	0.17	0.73 (0.12-4.24)	0.722
HR-HPV no 16, 18	10.2 (n 30)	7.8 (n 23)	12.6 (n 37)	0.31	0.97 (0.52-1.80)	0.917
HR-HPV no 16, 18, 31	9.5 (n 28)	7.5 (n 22)	11.2 (n 33)	0.38	0.97 (0.52-1.83)	0.934
HR-HPV no 16, 18, 31, 33, 45	8.5 (n 25)	7.5 (n 22)	10.9 (n 32)	0.65	1.09 (0.57-2.08)	0.786
LR non-vaccine types	5.4 (n 16)	5.1 (n 15)	6.8 (n 20)	0.87	1.26 (0.58-2.76)	0.560

types, HPV prevalence was not stratified by vaccination status
HR high risk, LR low risk, OR odds ratio, aOR adjusted OR, CI confidence interval, NE not estimable
^aAssociation adjusted for the following variables: marital status, smoking status, number of sexual partners in the past 6 months, number of lifetime sexual partners, and sexually transmitted diseases
^bComparison between unvaccinated and vaccinated before sexual debut. Note: nine cases of vaccinated women for whom there was no information about age at first sexual intercourse were excluded from the analysis
^cHPV33, 35, 43, 45, and 68 were tested but as the overall number of positive sample was <10 for each of these

ISSN: 1471-2334