A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre

BMC Infectious Diseases

Table 2 The change in sensitivity profile in recurrence patients with paired isolates

Recurrence classification	Number of cases (29)	Primary episode sensitivity profile	Recurrence episode sensitivity profile
Recurrence	10	Sensitive	Sensitive
Reinfection	2	Sensitive	Sensitive
Reinfection	1	H resistant	H resistant
Relapse	11	Sensitive	Sensitive
	1	Sensitive	R resistant
	1	Q & H resistant	H resistant (Q not tested)
	1	H resistant	RH resistant
	1	RHZQ resistant	RHZEQ resistant
	1	RHZE resistant	RHZE resistant

R rifampicin, H isoniazid, Z pyrazinamide, E ethambutol, Q Quinolone
Recurrence: two episodes of tuberculosis characterized by paired cultures positive for Mtb without MIRU-VNTR strain typing performed; Relapse: ≤ 1 MIRU-VNTR locus difference between isolates; Reinfection: ≥2 MIRU-VNTR loci differences

ISSN: 1471-2334