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Table 1 Cohort demographics

From: A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre

  Case (n = 82) N (%) Control (n = 164) N (%) P value
Age (year, +/−SD) 40.2 +/−17.6 37.4 +/−17.6 0.23
Weight (kg)a 56 (45.5–68)** 59 (48–68)** 0.26
Gender
 Male 42 (51.2) 84 (51.2)
 Female 40 (48.8) 80 (48.8) 1.00
Ethnicity
 White 10 (12.2) 20 (12.2)
 Afro-Caribbean 7 (8.5) 17 (10.4) 0.78
 Indian subcontinent 61 (74.4) 125 (76.2) 1.0
 Other 4 (4.9) 2 (1.2) 0.18
Permanent residence 81 (98.8) 163 (99.4) 1.00
UK Bornb 25 (30.5) 37 (22.5) 0.16
Habitual alcohol consumptionc 17 (23.6) 20 (12.4) 0.03
Habitual tobacco smokingd 20 (26.3) 19 (11.7) 0.01
BCG vaccinatede 31 (79.5) 73 (81.1) 0.81
Comorbidities
 Diabetes mellitus 9 (11.0) 15 (9.2) 0.65
 Solid organ transplant± 0 1 (0.6) 1.00
 Cancer 0 3 (1.8) 0.55
 End stage renal failure 1 (1.2) 3 (1.8) 1.00
 Rheumatological conditions 3 (3.7) 1 (0.6) 0.11
 HIV-1 seropositivity 5 (6.1) 6 (3.7) 0.51
 Vitamin D deficiencyf 24 (64.8) 52 (69.3) 0.67
Laboratory
 Haemoglobing (g/dl +/−SD) 11.7+/−1.8 12.2+/−1.9 0.11
 White cell counth (×109 cells/L) 7.5 (6.0–9.6)** 7.7 (5.9–9.5)** 0.91
 Creatininei (μmol/l) 70.0 (61.5–79.0)** 71.0 (61.0–83.0)** 0.46
Primary disease site
 PTB 45 (54.8) 68 (41.4)
 PTB + EPTB 10 (12.2) 31 (19.0) 0.09
 EPTB 27 (33.0) 65 (39.6) 0.14
Pulmonary cavitation 19 (23.2) 23 (14.0) 0.11
Microbiology
 AFB smear positivej 30 (41.7) 42 (27.7) 0.01
 Mtb culture positivek 56 (76.7) 93 (66.9) 0.16
 Drug resistancel 7 (12.5) 6 (6.5) 0.24
Treatment
 Standard regimen 68 (82.9) 145 (88.4) 0.24
ADR
 No ADR 64 (78.0) 143 (87.2)
 Grade 1/2 4 (4.9) 7 (4.3) 0.74
 Grade 3/4 14 (17.1) 14 (8.5) 0.06
 Treatment interruption (days) 0 (0–0)** 0 (0–0)** 0.96
 Immunosuppressing drugs 17 (20.7) 16 (9.8) 0.03
 Duration (days) 168 (168–273)** 168 (168–274)** 0.50
  1. The missing data for case and controls is:
  2. a14&16; b2&2; c10&2; d6&2; e4374; f45&89; g8&15; h8&16; i6&17; j10&19; k9&25; l26&71
  3. SD standard deviation, HIV human immunodeficiency virus, PTB pulmonary tuberculosis, EPTB extrapulmonary tuberculosis, ADR adverse drug reaction, AFB acid fast bacillus, Mtb Mycobacterium tuberculosis, BCG bacillus Calmette–Guérin
  4. ±Renal transplant' ±Renal transplant' to its own line
  5. Psoriasis and rheumatoid arthritis
  6. **median value and interquartile range