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Table 5 Pathogens identified in 55 children with laboratory-confirmed CNS infection

From: The aetiologies of central nervous system infections in hospitalised Cambodian children

Pathogen, n (%)

1-11 m (n = 11)

1-4y (n = 20)

5-15y (n = 24)

Overall (n = 55)

P-value

Enterovirusa

2 (18.2)

8 (40.0)

11 (45.8)

21 (38.3)

0.1

Japanese encephalitis virus

1 (9.1)

7 (35.0)

9 (37.5)

17 (31.0)

0.1

Streptococcus pneumoniae

3 (27.2)

3 (15.0)

1 (4.2)

7 (12.7)

0.05

Escherichia coli

2 (18.2)

0 (0)

0 (0)

2 (3.6)

–

Mumps virus

0 (0)

0 (0)

2 (8.3)

2 (3.6)

–

Neisseria meningitidis

2 (18.2)

0 (0)

0 (0)

2 (3.6)

–

Cryptococcus neoformans

0 (0)

0 (0)

1 (4.2)

1 (1.8)

–

Haemophilus influenzae type b

1 (9.1)

0 (0)

0 (0)

1 (1.8)

–

Herpes simplex virus

0 (0)

1 (5.0)

0 (0)

1 (1.8)

–

Staphylococcus aureus

0 (0)

1 (5.0)

0 (0)

1 (1.8)

–

Parechovirus

0 (0)

0 (0)

0 (0)

0 (0)

–

Varicella zoster virus

0 (0)

0 (0)

0 (0)

0 (0)

–

  1. aAnother 4 children (all 5-15y) were enterovirus positive on deep sequencing (not part of the core diagnostic strategy)