Table 2 Analysis of the association between genotype polymorphism at rs738409 PNPLA3 and steatosis and advanced liver fibrosis in patients with HCV infection according to the univariate and multivariate analysis in the recessive model
Variables | na/Nb (%) | na/Nb (%) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|
No steatosis | Steatosis | ORc | 95% CI | P | OR | 95% CI | P | |
PNPLA3 genotype | ||||||||
CC/CG | 108/147 (74.1) | 88/143 (61.5) | 1.00 | 1.00 | ||||
GG | 38/147 (25.9) | 55/143 (38.5) | 1.73 | (1.05 – 2.84) | 0.03 | 2.16 | (1.26 – 3.72) | 0.01 |
Age (years) | 52.2±11.7 | 57.6±11.8 | 0.03 | (0.01 – 0.06) | 0.00 | 1.04 | (1.02 – 1.06) | 0.00 |
Sex | ||||||||
Female | 78/147 (53.1) | 88/143 (61.5) | 1.00 | 1.00 | ||||
Male | 69/147 (46.9) | 55/143(38.6) | 1.41 | (0.88 – 2.25) | 0.14 | 0.62 | (0.35 – 1.08) | 0.09 |
BMI (kg/m2) | 26±3.8 | 28.1±7.6 | 0.07 | (0.03 – 0.13) | 0.00 | 1.10 | (1.04 – 1.18) | 0.00 |
Ethnicity/color | ||||||||
White | 108/147 (73.5) | 118/143 (82.5) | 1.00 | 1.00 | ||||
Pardo | 28/147 (19.0) | 15/143(10.5) | 0.64 | (0.33 – 1.24) | 0.19 | 0.77 | (0.36 – 1.66) | 0.50 |
Black | 11/147 (7.5) | 10/143 (7.0) | 1.34 | (0.53 – 3.23) | 0.55 | 0.71 | (0.25 – 2.05) | 0.53 |
HOMA-IR | 3.1±8.2 | 3.8±3.7 | 0.02 | (0.01 – 0.07) | 0.38 | 0.99 | (0.95 – 1.03) | 0.72 |
Alcohol | ||||||||
<20 g/day | 113/147 (76.9) | 117/143 (81.8) | 1.00 | 1.00 | ||||
>20 g/day | 31/147 (21.1) | 24/143(16.8) | 0.75 | (0.41 – 1.36) | 0.35 | 1.38 | (0.77 – 2.48) | 0.29 |
HCV genotype | ||||||||
Non 3 | 130/147 (88.4) | 111/143 (77.6) | 1.00 | 1.00 | ||||
3 | 15/147 (10.2) | 29/143(20.3) | 2.34 | (1.19 – 4.57) | 0.01 | 2.15 | (1.02 – 4.53) | 0.04 |
TM6SF2 (genotype | ||||||||
CC | 135/147 (91.8) | 126/143 (88.1) | 1.00 | 1.00 | ||||
CT | 12/147 (8.2) | 17/143(11.9) | 0.95 | (0.44 – 2.05) | 0.90 | 2.28 | (0.93 – 5.61) | 0.07 |
Mild fibrosis (F0-F1-F2) | Advanced Fibrosis (F3-F4) | |||||||
PNPLA3 genotype | ||||||||
CC/CG | 162/232 (69.8) | 34/58 (58.6) | 1.00 | 1.00 | ||||
GG | 70/232 (30.2) | 24/58(41.4) | 1.63 | (1.15 – 2.95) | 0.01 | 2.64 | (1.26 – 5.53) | 0.01 |
Age (years) | 53.4±13.3 | 60.7±9.2(84.5) | 0.05 | (0.02 – 0.08) | 0.00 | 1.08 | (1.04 – 1.11) | 0.00 |
Sex | ||||||||
Female | 145/232 (62.5) | 21/58 (36.2) | 1.00 | 1.00 | ||||
Male | 87/232 (37.5) | 37/58(63.8) | 2.93 | (1.61 – 5.33) | 0.00 | 1.06 | (1.03 – 1.09) | 0.00 |
BMI (kg/m2) | 27.1±6.4 | 26.8±4.8 | 1.00 | (0.95 – 1.05) | 0.71 | 1.03 | (0.97 – 1.09) | 0.37 |
Ethnicity/color | ||||||||
White | 183/232 (78.9) | 43/58 (74.1) | 1.00 | 1.00 | ||||
Pardo | 16/232 (6.9) | 10/58(17.3) | 1.36 | (0.62 – 2.99) | 0.43 | 2.46 | (0.93 – 6.48) | 0.07 |
Black | 33/232 (14.2) | 5/58(8.6) | 2.25 | (0.85 – 5.94) | 0.10 | 1.76 | (0.45 – 6.93) | 0.42 |
HOMA-IR | 3.2±6.7 | 4.6±4.5 | 0.02 | (0.01 – 1.02) | 0.21 | 1.03 | (0.99 – 1.08) | 0.15 |
Alcohol | ||||||||
<20 g/day | 187/232 (80.6) | 43/58 (74.1) | 1.00 | 1.00 | ||||
>20 g/day | 40/232 (17.2) | 15/58(25.9) | 0.59 | (0.30 – 1.17) | 0.13 | 0.91 | (0.39 – 2.12) | 0.82 |
HCV genotype | ||||||||
Non 3 | 196/232 (84.5) | 45/58 (77.6) | 1.00 | 1.00 | ||||
3 | 32/232 (13.8) | 13/58(22.4) | 1.76 | (0.86 – 3.64) | 0.12 | 1.43 | (0.59 – 3.45) | 0.43 |
TM6SF2 (genotype | ||||||||
CC | 215/232 (92.7) | 46/58 (79.3) | 1.00 | 1.00 | ||||
CT | 17/232 (7.3) | 12/58(20.7) | 3.51 | (1.18 – 10.47) | 0.02 | 4.81 | (1.67 – 13.87) | 0.00 |