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Table 3 Predictors of progression from normal haematocrit pre-treatment to anaemia within one week post-initiation of artemisinin-based combination treatments in <5 year-old children with uncomplicated falciparum malaria

From: Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials

Variable Total no. No. with anaemia 1 week post-initiation of ACTs OR (95% CI) P value AOR (95% CI) P value
Gender
 Female 278 132 1    
 Male 325 168 0.8 (0.6–1.2) 0.34
Age (month)
 > 15 541 255 1   1  
 ≤ 15 58 42 2.9 (1.6–5.4) < 0.0001 2.5 (1.4–4.7) 0.003
Duration of illness (day)
 ≤ 2 203 101 1    
 > 2 192 100 1.0 (0.7–1.6) 1.0
Enrolment body temperature (°C)
 ≤ 37.4 214 104 1    
 > 37.4 390 197 1.1 (1.0–1.9) 0.71
History of fever at enrolment
 Absent 99 39 1   1  
 Present 505 262 1.7 (1.1–2.6) 0.03 1.8 (1.1–2.9) 0.01
Fever on day 1
 Absent 501 255 1    
 Present 70 38 1.1 (0.7–1.9) 0.69
Haematocrit (%)
 > 35 140 42 1   1  
 ≤ 35 464 259 2.9 (2.0–4.4) < 0.0001 2.9 (1.9–4.4) <0.0001
Parasitaemia (μL−1)
 ≤ 50,000 434 213 1    
 > 50,000 166 87 1.1 (0.8–1.6) 0.52
Parasitaemia on day 1
 Absent 244 111 1    
 Present 360 190 1.3 (1.0–1.9) 0.09
Parasitaemia day 1 or 2
 Absent 233 104 1   1  
 Present 371 197 1.4 (1.0–2.0) 0.04 1.3 (0.9–1.9) 0.11
Gametocytaemia
 Absent 579 289 1    
 Present 25 12 0.9 (0.4–2.1) 1.0
Parasite clearance time (day)
 ≤ 2 468 234 1    
 > 2 136 67 1.0 (0.7–1.4) 0.96
Fever clearance time (day)
 ≤ 2 367 186 1    
 > 2 13 9 1.9 (0.9–4.3) 0.13
Season of enrolment
 Dry (November–March) 45 17 1    
 Wet (April–October) 559 284 1.7 (0.9–3.2) 0.13
Drug treatment
 DHP 226 110 1    
 AL 191 101 1.2 (0.8–1.7) 0.49
 AA 187 90 1.0 (0.7–1.4) 1.0   
  1. OR odd ratio, AOR adjusted odd ratio, CI confidence interval, DHP dihydroartemisinin-piperaquine, AL artemether-lumefantrine, AA artesunate-amodiaquine, ACTs artemisinin-based combination treatments