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Table 3 Specific gene mutations in resistant strains

From: Genotyping and drug susceptibility testing of mycobacterial isolates from population-based tuberculosis prevalence survey in Ghana

Gene locus

Band

Gene region/mutation

aRIF monoresistant

bINH monoresistant

cMDR

rpoB

     
 

WT1

506–509

   
 

WT2

510–513

   
 

WT3

513–517

  

d1

 

WT4

516–519

   
 

WT5

518–522

   
 

WT6

521–525

   
 

WT7

526–529

  

d3

 

WT8

530–533

1

 

1

 

MUT1

D516V

  

6

 

MUT2A

H526Y

  

d3

 

MUT2B

H526D

   
 

MUT3

S531 L

1

 

1

katG

     
 

WT

315

 

d11

d4

 

MUT1

S315 T1

 

14

10

 

MUT2

S315 T2

   

inhA

     
 

WT1

−15/−16

 

d4

d1

 

WT2

−8

  

d1

 

MUT1

C15T

 

d4

d1

 

MUT2

A16G

   
 

MUT3A

T8C

  

6

 

MUT3B

T8A

   
  1. WT wild type band, MUT mutant band, RIF rifampicin, INH isoniazid, MDR multi-drug resistance
  2. aIsolates with mutation(s) in the rpoB gene and none in the inhApro or katG gene
  3. bIsolates with mutation(s) in the inhApro region and/or in the katG gene, with no mutation in the rpoB gene
  4. cIsolates with mutations in the rpoB gene and inhApro and/or katG gene
  5. dNumber of isolates that had presence of mutation band and the absence of corresponding wild type band