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Table 2 Sensitivity and specificity of LAg-Avidity, BED and the decision tree for longitudinal seroconverter samples

From: Decision tree for accurate infection timing in individuals newly diagnosed with HIV-1 infection

     

Decision tree

Duration of infection (days)

Recent infection (n)

Long term infection (n)

LAg-Avidity EIA

BED CEIA

Classification 1

Classification 2

Sensitivity

Specificity

Sensitivity

Specificity

Sensitivity

Specificity

Sensitivity

Specificity

110

87

150

0.94

0.93

1.00

0.79

0.95

0.93

1.00

0.79

120

92

145

0.93

0.96

1.00

0.81

0.95

0.96

1.00

0.81

130

96

141

0.91

0.96

0.98

0.82

0.92

0.96

0.98

0.82

140

99

138

0.88

0.96

0.97

0.83

0.89

0.96

0.97

0.83

150

103

134

0.84

0.96

0.97

0.86

0.85

0.96

0.97

0.86

160

104

133

0.84

0.96

0.97

0.86

0.85

0.96

0.97

0.86

170

109

128

0.81

0.97

0.95

0.88

0.82

0.97

0.95

0.88

180

113

124

0.79

0.98

0.93

0.89

0.80

0.98

0.93

0.89

  1. Different recency windows were applied by changing the cut-off for duration of infection. The duration of infection is the periods (in days) after collection of the first pre-seroconversion sample. Recent infection: samples taken before the cut-off set for duration of infection, long term infection: samples taken at or after the cut-off set for duration of infection. For the decision tree, either all ‘very early’ and ‘early’ results were considered as recent (classification 1) or all ‘very early’, ‘early’ and ‘recent’ results were considered as recent (classification 2)
  2. Abbreviations: n number, EIA Enzyme Immuno Assay, CEIA Capture Enzyme Immuno Assay
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BMC Infectious Diseases

ISSN: 1471-2334

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