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Table 2 Sensitivity and specificity of LAg-Avidity, BED and the decision tree for longitudinal seroconverter samples

From: Decision tree for accurate infection timing in individuals newly diagnosed with HIV-1 infection

      Decision tree
Duration of infection (days) Recent infection (n) Long term infection (n) LAg-Avidity EIA BED CEIA Classification 1 Classification 2
Sensitivity Specificity Sensitivity Specificity Sensitivity Specificity Sensitivity Specificity
110 87 150 0.94 0.93 1.00 0.79 0.95 0.93 1.00 0.79
120 92 145 0.93 0.96 1.00 0.81 0.95 0.96 1.00 0.81
130 96 141 0.91 0.96 0.98 0.82 0.92 0.96 0.98 0.82
140 99 138 0.88 0.96 0.97 0.83 0.89 0.96 0.97 0.83
150 103 134 0.84 0.96 0.97 0.86 0.85 0.96 0.97 0.86
160 104 133 0.84 0.96 0.97 0.86 0.85 0.96 0.97 0.86
170 109 128 0.81 0.97 0.95 0.88 0.82 0.97 0.95 0.88
180 113 124 0.79 0.98 0.93 0.89 0.80 0.98 0.93 0.89
  1. Different recency windows were applied by changing the cut-off for duration of infection. The duration of infection is the periods (in days) after collection of the first pre-seroconversion sample. Recent infection: samples taken before the cut-off set for duration of infection, long term infection: samples taken at or after the cut-off set for duration of infection. For the decision tree, either all ‘very early’ and ‘early’ results were considered as recent (classification 1) or all ‘very early’, ‘early’ and ‘recent’ results were considered as recent (classification 2)
  2. Abbreviations: n number, EIA Enzyme Immuno Assay, CEIA Capture Enzyme Immuno Assay