Variables | 2009–2010 Pandemic (n = 16) | 2012–2016 Postpandemic (n = 60) | p value |
---|---|---|---|
Delay from symptoms to hospital admission, hours | 108.0 (48–168) | 72 (24–168) | 0.37 |
Delay from hospital admission to ICU admission, days | 1.9 (1.12–4.78) | 1.04 (0.07–2.18) | 0.25 |
Principal symptoms | |||
fever | 10 (66.7) | 43(71.7) | 0.06 |
dyspnea | 10 (62.5) | 52 (86.7) | 0.037 |
cough | 11 (68.8) | 28 (46.7) | 0.16 |
gastrointestinal | 5 (31.3) | 13 (21.7) | 0.51 |
neurological | 1 (6.3) | 15 (25) | 0.17 |
PaO2/FiO2, kPa | 33.4 (16.5–40.6) | 26.3 (15.0–42.6) | 0.41 |
Pneumonia on chest x-ray | 11 (68.8) | 53 (88.3) | 0.11 |
Bilateral opacities | 11 (100.0) | 49 (92.5) | 0.16 |
ARDS | 0.69 | ||
No | 5 (31.3) | 17 (28.3) | |
Mild | 2 (12.5) | 3 (5.0) | |
Moderate | 3 (18.8) | 14 (23.3) | |
Severe | 6 (37.5) | 26 (43.3) | |
Presence of bacteremia on admission | 0 | 5 (10) | 0.33 |
Mixed bacterial infection | 7 (43.8) | 9 (15) | 0.033 |
Antiviral treatment on ICU admission | 13 (81.3) | 45 (75) | 0.75 |
Bacterial antibiotics | 15 (93.8) | 48 (82) | 0.48 |