|
Variables
|
2009–2010 Pandemic (n = 16)
|
2012–2016 Postpandemic (n = 60)
|
p value
|
|---|
|
Male sex
|
8 (50)
|
42 (70)
|
0.15
|
|
Age, years
|
43 (32–53)
|
60 (50–65)
|
< 0.001
|
|
BMI
|
29.7 (24.0–36.1)
|
27.1 (24.5–32.4)
|
0.55
|
|
BMI 30–40
|
6 (37)
|
13 (22)
| |
|
BMI > 40
|
2 (12.5)
|
6 (10.2)
|
0.4
|
|
Chronic underlying disease
|
14 (87.5)
|
49 (83)
|
0.7
|
|
Cardiovascular
|
1 (6.3)
|
24 (40)
|
0.015
|
|
COPD/asthma
|
5 (31,3)
|
18 (30.0)
|
>0.9
|
|
Diabetes
|
6 (37.5)
|
9 (15.0)
|
0.07
|
|
Malignancy or immuno- suppressive medicationa
|
1 (6.3)
|
9 (15.0)
|
0.7
|
|
Epilepsy or other neurological disease
|
6 (37.5)
|
5 (8.3)
|
0.009
|
|
APACHE II score on admission
|
14 (10–17)
|
17 (13–22)
|
0.002
|
|
SAPS II score on admission
|
31 (25–35)
|
40 (31–51)
|
0.002
|
|
SOFA score on admission
|
5 (3–7)
|
6 (3–9)
|
0.31
|
|
SOFA score max
|
5 (4–9)
|
9 (5–12)
|
0.03
|
|
TISS score
|
34 (28–42)
|
39 (28–53)
|
0.40
|
|
LOS in ICU, days
|
1.9 (1.1–4.8)
|
4.3 (2.3–10.7)
|
0.31
|
|
LOS in hospital, days
|
8.2 (4.6–10)
|
13.0 (6.9–23.3)
|
0.009
|
|
ICU mortality
|
0
|
6 (10)
|
0.33
|
|
Hospital mortality
|
0
|
10 (16.7)
|
0.11
|
|
6-month mortality
|
2 (12.5)
|
15 (25)
|
0.5
|
-
APACHE Acute Physiology and Chronic Health Evaluation, BMI body mass index, ICU intensive care unit, LOS length of stay, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, TISS Therapeutic Intervention Scoring System
-
alymphoma, n = 2; leukemia, n = 2; carcinoma, n = 1; long-lasting immunosuppressive medication, n = 5
- Values are presented as median (25th–75th percentile) or number (percentage) of patients. Chronic underlying diseases included previously diagnosed chronic obstructive pulmonary disease, ischemic heart disease, chronic hepatic disease, chronic renal disease, previous stroke or transient ischemic attack, diabetes, and malignancy or immunosuppressive medication. Some patients had more than one chronic underlying disease
