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Table 3 Factors associated with end of MDR-TB treatment outcomes in Brazil, multivariate analysis

From: Treatment outcomes of MDR-tuberculosis patients in Brazil: a retrospective cohort analysis

  Adjusted odds of treatment success (cure/completed) vs. failure/relapse
(N = 1,302)
OR (95% CI)
Adjusted odds of treatment success (cure/completed) vs. failure/relapse/death
(N = 1,483)
OR (95% CI)
Adjusted odds of treatment success (cure/completed) vs. failure/relapse/death/lost to follow-up
(N = 1,864)
OR (95% CI)
HIV
 No 1.7 (0.9; 3.4) 2.7 (1.7; 4.2) 2.3 (1.6; 3.4)
 Yes Reference Reference Reference
Regimen
 Standardized 2.7 (1.8; 3.9) 1.4 (1.1; 1.9) 1.0 (0.8; 1.3)
 Individualized Reference Reference Reference
First DR-TB episode
 Yes 8.8 (5.7; 13.5) 5.4 (3.8; 7.7) 2.1 (1.1; 4.1)
 No Reference Reference Reference
AFB positive
 No 4.2 (2.1; 8.2) 2.1 (1.4; 3.1) 2.1 (1.5; 2.8)
 Yes Reference Reference Reference
Bilateral disease   
 No   1.4 (1.1.; 1.9) 1.3 (1.1; 1.6)
 Yes   Reference Reference
Number of previous regimens 0.4 (0.2; 0.7)
Diabetes  
 No/Unknown    0.7 (0.5; 0.9)
 Yes    Reference
Macro-region   
 North 0.9 (0.3; 2.2) 0.9 (0.5; 1.5)
 Northeastern 0.2 (0.1; 0.5) 0.4 (0.4; 0.7)  
 Centre-West 0.4 (0.1; 1.8) 1.0 (0.4; 2.6)  
 Southeastern 0.4 (0.2; 0.8) 0.7 (0.5; 1.1)  
 South Reference Reference  
  1. The variables that had a p- value <0.2 in the bivariate analysis entered in the initial multivariate-model (see Table 2). We performed a separate multivariate model for each group of outcome. Only variables that remained in the final model are shown. Bold font indicates statistically significant results (p-value < 0.05)
  2. Abbreviations: DR-TB Drug resistant tuberculosis, AFB acid fast bacilli