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Table 5 Effect of RP Result on Antibiotic Prescribing

From: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use

Antibiotic Prescribing Decision Category Control Intervention Total
number percent of control arm number percent intervention arm
Continue 128 60.7 165 49.4 293
De-escalate 5 2.4 6 1.8 11
Escalate 4 1.9 26 7.8 30
Start 1 0.5 17 5.1 18
Stop 7 3.3 15 4.5 22
Remain off antibiotics 51 24.1 95 28.4 146
Missing data about decision 15 7.1 10 3.0 25
Total 211   334   545
  1. Control arm de-escalate: 2 stop ≥1 antimicrobial, 3 substitution of Beta-lactam with narrower spectrum Beta-lactam. Intervention arm de-escalate: 2 stop ≥1 antimicrobial, 2 substitution of Beta-lactam with narrower spectrum Beta-lactam, 2 substitution of Beta-lactam with narrower spectrum Beta-lactam and atypical agent was stopped. Control arm escalate: 4 add antibiotic to existing antibiotics (all agents against atypical pneumonia). Intervention arm escalate: 19 add antibiotics to existing antibiotics (14 agents against atypical pneumonia, 5 addition of agents against ‘typical pneumonia’ to atypical agent e.g. Beta-lactam or teicoplanin with ciprofloxacin if penicillin allergic), 7 substitution of Beta-lactam with broader spectrum Beta-lactam