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Table 1 Diagnostic performance of qualitative vs quantitative HCV RNA NAT in five studies included in 2017 systematic review

From: The future of viral hepatitis testing: innovations in testing technologies and approaches

Author, year and country Sample type & number Study population Diagnostic test (Quantitative) Reference test
(Qualitative)
Sensitivity Specificity
Lee et al., 2000,
USA [9]
Serum
N = 51
Patients at risk of HCV infection Roche AMPLICOR HCV test, version 2.0 Roche COBAS AMPLICOR TM HCV Test v2.0 100% at 50 IU/mL;
91% at 25 IU/mL*
Yu et al., 2000, Taiwan [10] Serum
N = 215
Patients with chronic HCV Bayer bDNA-2 Quantiplex HCV test Roche COBAS AMPLICOR TM HCV Test v2.0 95%
Sabato et al., 2007, USA [11] Plasma
N = 76
Patients with HCV infection Bayer Versant HCV genotype assay Roche COBAS AMPLICOR TM HCV Test v1.0 100% 100%
Vermehren et al., 2008, Germany [12] Serum
N = 65
Patients with HCV Bayer Versant HCV genotype assay Abbott Real-Time Assay 87%
  1. *CAP/CTM Roche Cobas Ampliprep/ Cobas Taqman HCV assay, IU International Units