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Table 2 Variables Association with the Presence of Significant Fibrosis in the Training cohort by Univariate and Multivariate Analyses

From: Angiopoietin-like protein as a novel marker for liver fibrosis in chronic hepatitis B patients with normal to minimally raised ALT

Parameters

Univariate analysis

Multivariate analysis

F0–2 (n = 141)

F ≥ 3 (n = 82)

P

Exp (B) (95%CI)

P

Gender (Male, %)

113 (80.1%)

57 (69.5%)

0.076

1.219 (0.637, 2.332)

0.550

Age (≥35 year, %)

51 (36.2%)

47 (57.3%)

0.03

1.029 (0.988, 1.072)

0.165

BMI (≥24 kg/m2, %)

51 (36.2%)

31 (37.8%)

0.886

  

Platelet count (× 109/L)

190.68 ± 53.07

142.49 ± 49.17

<0.001

0.990 (0.985, 0.995)

0.001

ALT (IU/L)

42.99 ± 17.28

46.18 ± 16.68

0.159

0.987 (0.969, 1.005)

0.158

AST (IU/L)

31.46 ± 10.24

41.34 ± 18.53

<0.001

1.027 (1.008, 1.047)

0.005

ALP (IU/L)

72.03 ± 19.22

83.55 ± 24.05

0.001

1.006 (0.994, 1.017)

0.339

GGT (IU/L)

27.70 ± 21.92

59.06 ± 61.50

<0.001

1.005 (0.996, 1.013)

0.28

Albumin (g/L)

45.04 ± 4.97

43.27 ± 5.78

0.001

1.027 (0.973, 1.084)

0.334

TBil (μmol/L)

15.41 ± 19.93

16.01 ± 8.11

0.182

  

PT (s)

12.54 ± 1.14

13.10 ± 1.38

<0.001

1.067 (0.879, 1.296)

0.509

HBeAg (positive, %)

89 (63.1%)

47 (57.3%)

0.397

  

HBV DNA

(log10IU/ML)

6.43 ± 1.97

5.64 ± 1.77

<0.001

0.782 (0.603, 1.013)

0.063

Collagen IV (Pg/ML)

774.30 ± 302.67

1175.98 ± 887.97

<0.001

1.000 (0.999, 1.002)

0.472

Hyaluronic (μg/L)

97.83 ± 37.96

155.78 ± 86.27

<0.001

1.010 (1.004, 1.016)

0.002

Laminin (μg/L)

32.36 ± 50.72

196.10 ± 312.13

<0.001

1.004 (1.001, 1.006)

0.007

PIIINP (μg/L)

2.97 ± 5.79

4.85 ± 4.98

<0.001

0.968 (0.908, 1.103)

0.312

HBV DNA/HBeAg (n, %)

6.43 ± 1.97

5.64 ± 1.77

<0.001

0.782 (0.603, 1.013)

0.063

Angptl2 (ng/ml)

4.54 ± 1.96

6.07 ± 3.23

0.008

1.152 (1.039, 1.278)

0.007

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BMC Infectious Diseases

ISSN: 1471-2334

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