Correlates of isoniazid preventive therapy failure in child household contacts with infectious tuberculosis in high burden settings in Nairobi, Kenya – a cohort study

Table 3 Contact factors influencing IPT outcomes

Characteristics		TB disease	No TB disease	Fishers’ exact test (P value)	OR^a (95% CI)
Gender	Male	2	187	0.44	2.14
Gender	Female	4	175	0.44	0.39 –11.81
Contact age (months)	≤ 24 months	2	204	0.70	1.55
Contact age (months)	>24 months	4	158	0.70	0.28–8.57
Nutrition status^c	Malnutrition/ Weight faltering	3	40	0.02^b	0.124
Nutrition status^c	Normal	3	322	0.02^b	0.024–0.64
BGC scar	Positive	5	295	1.00	1.14
BGC scar	Negative	1	67	1.00	0.13–9.88
Breastfeeding currently	Yes	3	230	0.67	1.74
Breastfeeding currently	No	3	132	0.67	0.35–8.76
Appropriate weaning time	Yes	4	236	1.00	1.07
Appropriate weaning time	No	2	126	1.00	0.19–5.91
TB suggestive symptoms at enrollment^d	Yes	5	121	0.02^b	0.10
TB suggestive symptoms at enrollment^d	No	1	241	0.02^b	0.01–0.87
Birth weight	LBW (≥2500 g)	1	12	0.20	5.83
Birth weight	Normal (>2500 g)	5	350	0.20	0.63–53.86
Recent morbidity in last 3 months	Yes	1	40	0.51	0.62
Recent morbidity in last 3 months	No	5	322	0.51	0.07–5.45
Hospital admissions in last 1 year	Yes	5	49	0.59	0.78
Hospital admissions in last 1 year	No	1	313	0.59	0.09–6.84
Social place^e attendance	Yes	5	288	1.00	0.78
Social place^e attendance	No	1	74	1.00	0.90–6.74
Baseline TST	Positive	4	72	0.02^b	0.12
Baseline TST	Negative	2	290		0.02–0.69
HIV DNA PCR	Positive	3	22	0.01^b	0.06
HIV DNA PCR	Negative	3	340	0.01^b	0.01–0.34

^a OR is presented in the top cell and CI in lower cell. ^b Statistically significant factors, ^c malnutrition was present in those with any weight faltering on their growth charts and those who had under-nutrition <80%, ^d TB suggestive symptoms included those with cough ≥2 weeks, fever ≥2 weeks, weight loss, fatigue, reduced play, or any swellings. ^e Social places included churches, mosques, market places, or schools. TB tuberculosis, BCG Bacille Calmette-Guerin vaccine, LBW Low birth weight, HIV Human Immune Deficiency virus, DNA Deoxyribonucleic acid, PCR polymerase chain reaction, TST tuberculin skin test, CI confidence interval; OR odds ratio

ISSN: 1471-2334