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Table 3 Contact factors influencing IPT outcomes

From: Correlates of isoniazid preventive therapy failure in child household contacts with infectious tuberculosis in high burden settings in Nairobi, Kenya – a cohort study

Characteristics TB disease No TB disease Fishers’ exact test (P value) ORa
(95% CI)
Gender Male 2 187 0.44 2.14
Female 4 175 0.39 –11.81
Contact age (months) ≤ 24 months 2 204 0.70 1.55
>24 months 4 158 0.28–8.57
Nutrition statusc Malnutrition/ Weight faltering 3 40 0.02b 0.124
Normal 3 322 0.024–0.64
BGC scar Positive 5 295 1.00 1.14
Negative 1 67 0.13–9.88
Breastfeeding currently Yes 3 230 0.67 1.74
No 3 132 0.35–8.76
Appropriate weaning time Yes 4 236 1.00 1.07
No 2 126 0.19–5.91
TB suggestive symptoms at enrollmentd Yes 5 121 0.02b 0.10
No 1 241 0.01–0.87
Birth weight LBW (≥2500 g) 1 12 0.20 5.83
Normal (>2500 g) 5 350 0.63–53.86
Recent morbidity in last 3 months Yes 1 40 0.51 0.62
No 5 322 0.07–5.45
Hospital admissions in last 1 year Yes 5 49 0.59 0.78
No 1 313 0.09–6.84
Social placee attendance Yes 5 288 1.00 0.78
No 1 74 0.90–6.74
Baseline TST Positive 4 72 0.02b 0.12
Negative 2 290   0.02–0.69
HIV DNA PCR Positive 3 22 0.01b 0.06
Negative 3 340 0.01–0.34
  1. a OR is presented in the top cell and CI in lower cell. b Statistically significant factors, c malnutrition was present in those with any weight faltering on their growth charts and those who had under-nutrition <80%, d TB suggestive symptoms included those with cough 2 weeks, fever 2 weeks, weight loss, fatigue, reduced play, or any swellings. e Social places included churches, mosques, market places, or schools. TB tuberculosis, BCG Bacille Calmette-Guerin vaccine, LBW Low birth weight, HIV Human Immune Deficiency virus, DNA Deoxyribonucleic acid, PCR polymerase chain reaction, TST tuberculin skin test, CI confidence interval; OR odds ratio