Fig. 1

a Correlation between uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) polymorphisms and plasma dolutegravir (DTG) trough concentrations. The horizontal straight lines indicate the median values. The Wilcoxon rank-sum test revealed significant differences between the groups (p = 0.0008). Post-hoc testing was performed using the Steel’s test; a comparison was made to the normal allele group. * p < 0.05 and ** p < 0.01. b Plasma DTG trough concentrations with or without neuropsychiatric adverse events (NP-AEs) after the use of DTG. The Wilcoxon rank-sum test showed significant differences (** p = 0.0013)