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Table 5 Comparison of characteristics with favourable versus unfavourable outcomes

From: Treatment outcomes for isoniazid-resistant tuberculosis under program conditions in British Columbia, Canada

Characteristic (n, %) Successful outcomea
(n = 140)
Unsuccessful outcomeb
(n = 12)
P value
Patient characteristics
 Co-morbidity (HIV, DM, Malignancy, CKD, immune suppressive medication) 36 (25.7) 3 (25.0) 1.00
 Smear positive diseasec 64 (60.4) 5 (50.0) 0.523
 Cavitary diseasec 41 (38.7) 5 (50.0) 0.515
 Prior TB treatmentd 19 (14.4) 2 (22.2) 0.623
Resistance profile
 High level INH resistance 69 (49.3) 7 (58.3) 0.547
Treatment regimen
  > 2 months pyrazinamide 66 (47.1) 7 (58.3) 0.456
  > 9 months rifampin 69 (49.3) 3 (25.0) 0.106
  ≥ 4 effective drugs in intensive phase 25 (17.9) 3 (25.0) 0.464
 Fluoroquinolone containing regimen 52 (37.1) 4 (33.3) 0.793
  1. aA successful outcome included patients meeting the definition of Cure or Treatment Completed without Relapse
  2. bAn unsuccessful outcome included patients meeting the definition of Treatment Failure, Acquire Drug Resistance, Death, or Relapse
  3. cThe denominator used to calculate percentage for smear positive disease was based on those with pulmonary involvement and primary study outcome (successful outcome n = 106; unsuccessful outcome n = 10)
  4. dMissing data for 8 successful outcomes and 1 unsuccessful outcome