Table 2 Analysis of mutation in the preS1/S2/S gene reported to be associated with HCC and immune escape
From: Molecular characterization of hepatitis B virus in Vietnam
Nucleotide | Amino acid | All isolates N = 135% (n) | Genotype B N = 98 v | Genotype C N = 37% (n) | p value |
|---|---|---|---|---|---|
Mutation in preS1/S2 and S gene associated with HCC | |||||
PreS1 gene | |||||
A2962G | N38E | 71.9 (97) | 99.0 (97) | 0.0 (0) | 0.000 |
C2964A | N38 K | 71.1 (96) | 098.0 (96) | 0.0 (0) | 0.000 |
C3026A/T | A60V/E | 100 (135) | 100 (98) | 100 (37) | |
PreS2 gene | |||||
Start codon | M1 V/T/I | 6.7 (9) | 8.2 (8) | 2.1 (1) | 0.237 |
T53C | F22 l | 2.2 (3) | 3.1 (3) | 0.0 (0) | 0.379 |
A162G | N3S | 27.4 (37) | 0.0 (0) | 100 (37) | 0.000 |
T531C/G | L126 T/S | 77.0 (104) | 98.0 (96) | 21.6 (8) | 0.000 |
S gene | |||||
A706C | V184A | 3.7 (5) | 4.1 (4) | 2.7 (1) | 0.581 |
T766A | S204R | 4.4 (6) | 6.1 (6) | 0.0 (0) | 0.140 |
Mutation in S gene associated with immune escape | |||||
S gene | |||||
P120S/E | 2.2 (3) | 3.1 (3) | 0.0 (0) | 0.379 | |
I/T126A/N/I/S | 2.2 (3) | 3.1 (3) | 0.0 (0) | 0.379 | |
M133 L/T | 3.0 (4) | 4.1 (4) | 0.0 (0) | 0.273 | |
G145R | 0.7 (1) | 0.0 (0) | 2.7 (1) | 0.274 | |