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Table 4 Main serotypes of S. pneumoniae isolated from patients with invasive pneumococcal disease cared for in Regional Health Care Network 13, according to the isolation period,1998 to 2013

From: Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine

Serotypes 1998–2002 n = 222 Period Total p value
2003–2010 n = 479 Subtotal n = 701 2011–2013 n = 95 n = 796  
no %* no %* no % no %* no %
14 45 20.3 94 19.6 139 19.8 6 6.3 145 18.2 0.006
3 14 6.3 42 8.8 56 8.0 17 17.9 73 9.2 0.004
19F 15 6.8 28 5.8 43 6.1 3 3.2 46 5.8 0.451
1 12 5.4 31 6.5 43 6.1 0 0.0 43 5.4 0.039
6A 13 5.9 20 4.2 33 4.7 6 6.3 39 4.9 0.501
6B 7 3.2 27 5.6 34 4.9 4 4.2 38 4.8 0.344
23F 8 3.6 29 6.1 37 5.3 0 0.0 37 4.6 0.026
9V 6 2.7 25 5.2 31 4.4 3 3.2 34 4.3 0.262
18C 13 5.9 15 3.1 28 4.0 5 5.3 33 4.1 0.205
19A 13 5.9 18 3.8 31 4.4 2 2.1 33 4.1 0.245
12F 1 0.5 18 3.8 19 2.7 9 9.5 28 3.5 <0.001
4 8 3.6 13 2.7 21 3.0 3 3.2 24 3.0 0.811
7F 7 3.2 12 2.5 19 2.7 2 2.1 21 2.6 0.832
5 14 6.3 1 0.2 15 2.1 2 2.1 17 2.1 <0.001
11A 0 0.0 12 2.5 12 1.7 3 3.2 15 1.9 0.047
22F 3 1.4 12 2.5 15 2.1 0 0.0 15 1.9 0.206
8 2 0.9 5 1.0 7 1.0 5 5.3 12 1.5 0.006
9N 1 0.5 6 1.3 7 1.0 3 3.2 10 1.3 0.140
  1. %* refers to the total IPD cases in each period
  2. p values in bold are significant