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Table 3 Resistance for 1st line anti-TB drugs among M.tuberculosis isolates from presumed Drug Resistant TB cases in 5 Reference Centers - Brazil

From: Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil

Resistance Isolates from New cases (n = 87) Isolates from retreatment cases (n = 23)
N % (95% CI) N % (95% CI)
Fully susceptible 48 55.2(44.7–65.2) 11 50.0(30.7–69.3)
Any resistancea
 INH 35 40.2(30.5–50.7) 10 45.4(26.9–63.4)
 RMP 24 27.6(19.3–37.8) 7 31.8(16.2–52.8)
 EMB 16 18.4(11.5–27.9) 1 4.5(0.1–29.0)
 SM 14 16.1(9.7–25.3) 4 18.9(6.7–39.1)
 PZA 6 6.9(2.9–14.5) 1 4.5(0.1–29.0)
Multidrug resistance 22 25.3(17.3–35.4) 6 27.3(12.9–48.4)
 RMP + INH 7 8.1(3.7–15.5) 3 13.6(3.9–34.2)
 RMP + INH + EMB 2 2.3(0.1–6.7)
 RMP + INH + SM 1 1.2(0.05–6.7) 2 9.1(1.3–29.0)
 RMP + INH + EMB + SM 7 8.1(3.7–15.5)
Other forms of Resistance 5 5.7(2.2–13.1) 1 4.5(0.1–29.0)
 INH only 6 6.9(2.9–14.5) 2 9.1(1.3–29.0)
 RMP only 1 1.2(0.05–6.7)
 SM only 1 1.2(0.05–6.7) 1 4.5(0.1–29.0)
 EMB only 1 1.2(0.05–6.7)
 PZA only 1 1.2(0.05–6.7)
Number of drugs to which patients were resistant
 0 48 55.2(44.7–65.2) 11 50.0(30.7–69.3)
 1 10 11.5(6.2–20.1) 3 13.6(3.9–34.2)
 2 13 14.9(8.8–24.0) 4 18.9(6.7–39.1)
 3 5 5.7(2.2–13.1) 4 18.9(6.7–39.1)
 4 11 12.6(7.0–21.4) 1 50.0(30.7–69.3)
  1. RMP rifampicin, INH isoniazid, EMB ethambutol, SM streptomycin, PZA pyrazinamid, CI confidence intervals
  2. aAny resistance indicates resistance to the anti-tuberculosis medication tested, independent of resistance results to other medications