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Table 3 Resistance for 1st line anti-TB drugs among M.tuberculosis isolates from presumed Drug Resistant TB cases in 5 Reference Centers - Brazil

From: Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil

Resistance

Isolates from New cases (n = 87)

Isolates from retreatment cases (n = 23)

N

% (95% CI)

N

% (95% CI)

Fully susceptible

48

55.2(44.7–65.2)

11

50.0(30.7–69.3)

Any resistancea

 INH

35

40.2(30.5–50.7)

10

45.4(26.9–63.4)

 RMP

24

27.6(19.3–37.8)

7

31.8(16.2–52.8)

 EMB

16

18.4(11.5–27.9)

1

4.5(0.1–29.0)

 SM

14

16.1(9.7–25.3)

4

18.9(6.7–39.1)

 PZA

6

6.9(2.9–14.5)

1

4.5(0.1–29.0)

Multidrug resistance

22

25.3(17.3–35.4)

6

27.3(12.9–48.4)

 RMP + INH

7

8.1(3.7–15.5)

3

13.6(3.9–34.2)

 RMP + INH + EMB

2

2.3(0.1–6.7)

 RMP + INH + SM

1

1.2(0.05–6.7)

2

9.1(1.3–29.0)

 RMP + INH + EMB + SM

7

8.1(3.7–15.5)

Other forms of Resistance

5

5.7(2.2–13.1)

1

4.5(0.1–29.0)

 INH only

6

6.9(2.9–14.5)

2

9.1(1.3–29.0)

 RMP only

1

1.2(0.05–6.7)

 SM only

1

1.2(0.05–6.7)

1

4.5(0.1–29.0)

 EMB only

1

1.2(0.05–6.7)

 PZA only

1

1.2(0.05–6.7)

Number of drugs to which patients were resistant

 0

48

55.2(44.7–65.2)

11

50.0(30.7–69.3)

 1

10

11.5(6.2–20.1)

3

13.6(3.9–34.2)

 2

13

14.9(8.8–24.0)

4

18.9(6.7–39.1)

 3

5

5.7(2.2–13.1)

4

18.9(6.7–39.1)

 4

11

12.6(7.0–21.4)

1

50.0(30.7–69.3)

  1. RMP rifampicin, INH isoniazid, EMB ethambutol, SM streptomycin, PZA pyrazinamid, CI confidence intervals
  2. aAny resistance indicates resistance to the anti-tuberculosis medication tested, independent of resistance results to other medications